Drug mixing and delivery system and method

Inventors

Buchine, Brent A. • Standley, Adam R. • Stepanian, Christopher J.

Assignees

Windgaplegacyco LLC

Abstract

The present disclosure provides methods of preparing a medical solution. In some aspects, the medical solution can be prepared from mixing a first liquid with a second liquid or mixing a solid component with a liquid in an autoinjector. In some aspects, the heat released from the mixing can promote solubility of a dry medicament in the solution.

Core Innovation

The invention relates to an autoinjector that includes a dry chamber comprising a dry epinephrine composition and a wet chamber comprising a liquid acid composition. The dry chamber is sealed from the wet chamber prior to activation, and activation results in mixing the liquid acid composition from the wet chamber with the dry epinephrine composition from the dry chamber. This arrangement enables preparation of an epinephrine-containing medical solution by mixing the separated dry and liquid components.

The dry epinephrine composition is described as epinephrine free base or epinephrine salts, including epinephrine free base and epinephrine salts selected from maleate, malate, fumarate, tartrate, bitartrate, borate, hydrochloride, and related forms. The liquid acid composition is described as a liquid acid suitable to mix with the dry epinephrine composition after activation.

Mixing activation is associated with dissolution or reconstitution of the epinephrine component using heat generated from mixing, including exothermic acid/base neutralization. The disclosure further describes using a pH-optimized acid and, optionally, a pH adjusting solution or buffer to support reconstitution.

Claims Coverage

The independent claim is an autoinjector with a sealed dry chamber holding a dry epinephrine composition and a sealed wet chamber holding a liquid acid composition, where activation mixes the separated components. The dependent claim set refines the epinephrine form and characterizes the liquid acid composition, including by specific acid species and pH constraints.

Across the claim set, the core inventive structure is the autoinjector with a sealed dry chamber containing a dry epinephrine composition and a sealed wet chamber containing a liquid acid composition, with activation causing mixing of the separated components. Dependent features further specify epinephrine form, including L-epinephrine free base, and constrain the liquid acid by named acid species and pH, while also specifying possible epinephrine salt anion forms.

Stated Advantages

Documented Applications