Fluoropolymer based anti-thrombotic coatings
Inventors
Bandyopadhyay, Saibal • Jones, Andrew K.
Assignees
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Publication Number
US-12233186-B2
Publication Date
2025-02-25
Expiration Date
Abstract
The present disclosure provides for medical devices comprising one or more components comprised of a fluoropolymer and/or perfluorinated polymer and a liquid comprised of one or more fluorinated and/or perfluorinated liquids, wherein at least a portion of a surface of the one or more components comprised of a fluoropolymer and/or perfluorinated polymer comprises a surface layer of the fluorinated and/or perfluorinated liquid.
Core Innovation
The invention relates to a medical device that includes one or more components comprised of one or more perfluorinated polymers and a liquid comprised of one or more perfluorinated liquids. At least a portion of a surface of the perfluorinated-polymer components includes a surface layer of the one or more perfluorinated liquids.
The invention addresses thrombogenicity and biofilm adhesion associated with medical device surfaces by providing a fluoropolymer- or perfluoropolymer-based anti-thrombotic and anti-biofilm coating. The surface roughness is constrained using a ratio of an actual surface area divided by a projected surface area that is greater than 1.00, and the roughness is determined in the absence of the perfluorinated liquids.
In representative disclosures, the perfluorinated polymers include fluorinated ethylene propylene (FEP) and polytetrafluoroethylene (PTFE) and combinations thereof. The perfluorinated liquids include perfluorodecalin and perfluorotributylamine and combinations thereof, and the disclosed configuration is associated with reduced biofilm and reduced clot/thrombus formation compared to untreated counterparts.
Claims Coverage
The partial set identifies one independent claim. Across this independent claim, the coverage centers on a medical device formed from perfluorinated polymers combined with perfluorinated liquids to form a surface layer, with an inventive emphasis on a defined surface roughness metric determined without the liquid and on specified perfluorinated polymer and liquid chemistries.
Medical device with perfluorinated polymer component and perfluorinated liquid surface layer
A medical device comprising one or more components comprised of one or more perfluorinated polymers and a liquid comprised of one or more perfluorinated liquids, wherein at least a portion of a surface of the one or more components comprises a surface layer of the one or more perfluorinated liquids.
Defined surface roughness metric determined without the perfluorinated liquids
Greater than 50% of a surface of the one or more components that comprises a layer of the one or more perfluorinated liquids has a roughness defined by a ratio of an actual surface area divided by a projected surface area greater than 1.00, wherein the roughness is determined in the absence of the one or more perfluorinated liquids.
Perfluorinated polymers comprising FEP and/or PTFE
The one or more perfluorinated polymers comprises fluorinated ethylene propylene (FEP), polytetrafluoroethylene (PTFE), or a combination thereof.
Perfluorinated liquids comprising perfluorodecalin and/or perfluorotributylamine
The one or more perfluorinated liquids comprises perfluorodecalin, perfluorotributylamine or a combination thereof.
The independent claim coverage focuses on a medical device whose perfluorinated polymer surfaces include a surface layer of perfluorinated liquids, where a majority of the liquid-layer surface area exhibits roughness above 1.00 as determined without the liquid, and where the selected polymer and liquid chemistries are limited to FEP/PTFE and perfluorodecalin/perfluorotributylamine.
Stated Advantages
Reduced biofilm and reduced clot/thrombus formation compared to untreated counterparts.
Documented Applications
Medical devices including catheters and PICC lines used in clot/thrombus and biofilm contexts.
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