Methods and devices to reduce the risk of infection
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Publication Number
US-12232962-B2
Publication Date
2025-02-25
Expiration Date
Abstract
Articles for reducing the risk of infection, bearing, or containing an antimicrobial composition containing a solid-phase peroxyxcarboxylic acid metal salt are provided. Methods of reducing the risk of infection using the antimicrobial composition are also provided.
Core Innovation
The invention relates to infection-reducing articles and methods that use a solid-phase peroxycarboxylic acid metal salt formed as a reaction product in a polymer matrix support. The antimicrobial composition is dried to form a solid-phase precipitate on a surface configured for tissue contact, and the reaction mixture includes hydrogen peroxide, peracetic acid, acetic acid, and a basic metal salt selected from magnesium, zinc, and lithium metal salts.
The basic metal salt is present in an amount effective to adjust the composition pH to between 3.5 and 7.5, and the resulting coating has a thickness of at least 10 4m. The described article forms include wipes, dressings, surgical drapes, and implant types including orthopedic and endosteal implant forms.
The documented description ties the infection reduction to moisture-triggered release and a proposed oxidative mechanism involving breach of microbial cells. The solid-phase compositions are presented as improving stability and handling compared with liquid controls, and as maintaining antimicrobial efficacy even against microbes described as antibiotic-resistant.
Claims Coverage
The partial content provides one independent claim directed to a tissue-contact article with a specific dried solid-phase antimicrobial coating. It also includes dependent-claim refinements, including defined content and pH constraints, selection of basic metal salt forms, and narrowing to implant articles.
Dried solid-phase peracetic acid metal salt precipitate antimicrobial coating
An article configured for tissue contact includes a surface coated with an antimicrobial composition consisting of a dried solid-phase peracetic acid metal salt precipitate formed as a reaction product of a mixture including a polymer matrix support, hydrogen peroxide, peracetic acid, acetic acid and a basic metal salt selected from magnesium, zinc and lithium metal salts.
pH-adjusting basic metal salt within 3.5 to 7.5
The basic metal salt is present in an amount effective to adjust the composition pH to between 3.5 and 7.5.
Coating thickness at least 10 4m
The antimicrobial composition coating has a thickness of at least 10 4m.
Defined peracetic acid content range in the mixture
The peracetic acid amount in the mixture is within 0.1% to 85%.
Acetic acid concentration of 2.75 M in the mixture
The acetic acid concentration in the mixture is 2.75 M.
Basic metal salt to peracetic acid molar ratio 0.1:1 to 10:1
The basic metal salt and peracetic acid are present in a molar ratio ranging from about 0.1:1 to about 10:1.
Basic metal salt can include carbonates, hydroxides, oxides, acetates, formates, or related salts
The basic metal salt can be a carbonate, hydroxide, oxide, acetate, or formate metal salt, or a metal salt of an organic acid that corresponds to the reduced form of peracetic acid.
Implant tissue-contact article
The claimed article is an implant.
Across the independent claim and its refinements, coverage centers on a tissue-contact surface coated with a dried solid-phase peracetic acid metal salt precipitate generated from hydrogen peroxide, peracetic acid, acetic acid, and a basic metal salt selected from magnesium, zinc, and lithium metal salts effective to achieve pH 3.57.5, with a coating thickness of at least 10 4m. Dependent features further constrain peracetic acid amount, acetic acid concentration, and basic metal salt:peracetic acid molar ratio, expand acceptable basic-metal-salt forms, and narrow the article type to an implant.
Stated Advantages
Moisture-triggered release
Improved stability and handling
Reduced risk of infection even against antibiotic-resistant microbes
Proposed oxidative breach of microbial cells as the mechanism for antimicrobial activity
Demonstrated antimicrobial efficacy for solid-phase compositions comparable to liquid controls
Magnesium salts improve peracid/peracetic acid retention during drying and aging
Sterilization resistance with retained measurable peracid
Humidity sensitivity showing failure under higher humidity conditions and success under lower-humidity/desiccant-like conditions
Documented Applications
Articles configured for tissue contact including wipes, bandage or dressing, and surgical drapes
Implant types including orthopedic/endosteal/articular implants and other listed implant categories such as pacemaker/lead-type and stent-type implant examples
Bioabsorbable implant variants and layered implant envelope/mesh configurations
Compatibility with negative pressure wound therapy
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