2D and 3D bioscaffold extracellular structural unit and tissue structure design and methods of manufacture
Inventors
Toro Estrella, Hector Javier • GARCIA, ORQUIDEA HELEN
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12226547-B2
Publication Date
2025-02-18
Expiration Date
Abstract
A bioscaffold structure is provided, the bioscaffold comprising a plurality of connected unit cells, each unit cell comprising a plurality of filaments composed of an extracellular material containing Collagen I and Collagen III, wherein each of the plurality of unit cells includes at least one opening connected to an internal volume.
Core Innovation
The invention relates to a bioscaffold structure that includes a plurality of 3D printed polymers. The polymers form a plurality of connected unit cells in which each unit cell includes at least one opening connected to an internal volume. The connected unit cells are at least partially coated with a collagen coating that comprises a specified Collagen I to Collagen III ratio.
In the described architecture, the connected unit cells make up a layer of fibers composed of an extracellular material containing the Collagen I to Collagen III ratio. The fiber layer includes a plurality of pores, and the pores are connected to an internal volume through openings in the unit cells. The collagen coating and pore/opening arrangement are part of the bioscaffold structure geometry and composition.
The scaffold design specifies a Collagen I to Collagen III ratio between about 0.75:1 and about 3.5:1. The disclosed structures further include design-controlled mechanical property ranges and scaffold-form factor options, including a substantially planar sheet or a 3D macrostructure.
Claims Coverage
The provided independent claims are clm-00001 and clm-00015. They share the same core concept of a bioscaffold structure formed by 3D printed polymers into connected unit cells with openings to an internal volume, and both require a collagen coating or fiber layer with a specified Collagen I to Collagen III ratio; clm-00015 further requires that the connected unit cells make up a fiber layer including pores.
Connected unit cells with openings to internal volume and collagen coating ratio
A bioscaffold structure comprising a plurality of 3D printed polymers; a plurality of connected unit cells formed from the plurality of 3D printed polymers, wherein each unit cell includes at least one opening connected to an internal volume; and the plurality of connected unit cells is at least partially coated with a collagen coating comprising a Collagen I to Collagen III ratio of between about 0.75:1 to about 3.5:1.
Fiber layer with pores and collagen ratio
A bioscaffold structure comprising a plurality of 3D printed polymers; a plurality of connected unit cells formed from the plurality of 3D printed polymers, wherein each unit cell includes at least one opening connected to an internal volume and wherein the plurality of connected unit cells makes up a layer of fibers composed of an extracellular material containing a Collagen I to Collagen III ratio of between about 0.75:1 to about 3.5:1; and wherein the layer includes a plurality of pores.
Overall, the independent claims cover bioscaffold structures formed from 3D printed polymers into connected unit cells with internal-volume-connected openings, combined with an extracellular collagen coating or fiber-layer collagen composition defined by a Collagen I:Collagen III ratio between about 0.75:1 and about 3.5:1; one claim additionally requires the unit-cell arrangement to constitute a fiber layer including pores.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?