On-line autocalibration method for a computer brain interface device and computer brain interface device
Inventors
Várkuti, Bálint • HAGH-GOOIE, SAMAN • Blischak, Brian
Assignees
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Publication Number
US-12214202-B2
Publication Date
2025-02-04
Expiration Date
Abstract
A computer brain interface (CBI) device of an individual is self-calibrated. A neurostimulation test signal is generated based on a selected set of test signal parameters. The neurostimulation signal is applied to the afferent sensory nerve fibers to elicit a bioelectric response via a neurostimulation interface operably connected to or integrated with the CBI device. The neurostimulation interface senses the bioelectric responses of the stimulated afferent sensory nerve fibers. The CBI devices determines, based on the sensed bioelectric responses, whether an excitation behavior of the stimulated afferent sensory nerve fibers with respect to the neurostimulation interface has changed. When the excitation behavior has changed, a set of recalibrated neurostimulation signal parameters is determined based on the sensed bioelectric responses. The CBI device is operated using the recalibrated neurostimulation signal parameters to communicate information to the individual via neurostimulation of the afferent sensory nerve fibers.
Core Innovation
The invention relates to a method and device for self-calibrating a computer brain interface (CBI) of an individual. A set of test signal parameters is selected to generate at least one neurostimulation test signal configured to elicit a bioelectric response in one or more afferent sensory nerve fibers. The neurostimulation test signal is applied via a neurostimulation interface that is operably connected to or integrated with the CBI device, and bioelectric responses of the stimulated afferent sensory nerve fibers are sensed via the neurostimulation interface.
The method determines, based on the sensed bioelectric responses, whether excitation behavior of the stimulated afferent sensory nerve fibers with respect to the neurostimulation interface has changed. When the excitation behavior has changed, the method determines a set of recalibrated neurostimulation signal parameters by comparing the sensed bioelectric responses to a set of reference bioelectric responses stored in a memory module of the CBI device or obtained via a communication interface of the CBI device. The CBI device is then operated using the recalibrated neurostimulation signal parameters to communicate information to the individual via neurostimulation of the one or more afferent sensory nerve fibers.
In associated implementations, the CBI device includes a neurostimulation interface comprising one or more stimulation and recording channels adapted to elicit and record bioelectric responses of afferent sensory nerve fibers terminating in a sensory cortex area of an individual. Data and signal processing circuitry selects test signal parameters, generates neurostimulation test signals, applies them via the neurostimulation interface, senses bioelectric responses, determines whether excitation behavior has changed, and determines recalibrated neurostimulation signal parameters. Reference bioelectric responses are associated with artificial sensations and, for communication, with one or more blocks of information.
Claims Coverage
Independent claims cover a method for self-calibrating a CBI by online sensing of bioelectric responses and recalibration based on reference bioelectric responses, a computer program performing the same functional sequence in a neurostimulation system, and a CBI device configured with stimulation and recording channels and data and signal processing circuitry to execute the self-calibration and communication workflow. The independent claims include at least four inventive feature clusters.
Test-signal elicitation and sensing of afferent sensory nerve fiber bioelectric responses
Select a set of test signal parameters; generate, based on the selected set, at least one neurostimulation test signal configured to elicit a bioelectric response in one or more afferent sensory nerve fibers; apply the generated neurostimulation test signal via a neurostimulation interface operably connected to or integrated with the CBI device; and sense via the neurostimulation interface one or more bioelectric responses of the stimulated afferent sensory nerve fibers.
Excitation behavior change detection and conditional recalibration
Determine, based on the sensed bioelectric responses, whether an excitation behavior of the stimulated afferent sensory nerve fibers with respect to the neurostimulation interface has changed; and when the excitation behavior has changed, determine a set of recalibrated neurostimulation signal parameters based on the sensed bioelectric responses.
Reference-based recalibration using stored or obtained reference bioelectric responses
Determine the set of recalibrated neurostimulation signal parameters by comparing the sensed bioelectric responses to a set of reference bioelectric responses stored in a memory module of the CBI device or obtained via a communication interface of the CBI device.
Communication using recalibrated neurostimulation signal parameters
Operate the CBI device, using the recalibrated neurostimulation signal parameters, to communicate information to the individual via neurostimulation of the one or more afferent sensory nerve fibers.
CBI device with stimulation and recording channels terminating in a sensory cortex area
Provide a neurostimulation interface comprising one or more stimulation and recording channels adapted to elicit and record a bioelectric response of one or more afferent sensory nerve fibers terminating in a sensory cortex area of an individual, and data and signal processing circuitry configured to perform selection of test signal parameters, generation and application of test signals, sensing of bioelectric responses, excitation behavior change determination, recalibrated parameter determination, and communication using recalibrated neurostimulation signal parameters.
The independent claims collectively require a CBI workflow in which neurostimulation test signals are used to elicit and sense bioelectric responses, excitation behavior changes are detected, and recalibrated neurostimulation signal parameters are determined by comparing sensed responses to reference bioelectric responses stored in a memory module of the CBI device or obtained via a communication interface. The recalibrated parameters are then used to operate the CBI device or neurostimulation device to communicate information to the individual.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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