Electrical condensation aerosol device
Inventors
HASEGAWA, David Koji • Lei, Mingzu • Tong, Gilbert T.
Assignees
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Publication Number
US-12214119-B2
Publication Date
2025-02-04
Expiration Date
Abstract
The present invention provides a method for producing condensation aerosols for the treatment of disease and/or chronic, intermittent or acute conditions. These condensation aerosols are produced from drugs including temperature sensitive drugs and small molecule drugs that are coated onto a foil substrate which is heated via electrical resistance heating at precisely controlled temperature profiles with controllable ramp-up and heating rates to vaporize the coated drug which subsequently condenses to form aerosol particles. These condensation aerosols have little or no degradation products. Kits comprising a drug and a device for producing a condensation aerosol are also provided. Also disclosed, are methods for using these aerosols and kits and methods of making the aerosols.
Core Innovation
The invention relates to an electrical condensation-aerosol drug delivery system that produces an alprazolam condensation aerosol by thermal vaporization of alprazolam. A disposable cartridge includes an alprazolam composition coated on a foil substrate, and a handheld medical device includes one or more air inlets and one or more air outlets defining an airway that conveys the resulting vapor for condensation inside the cartridge into aerosol particles.
The handheld medical device provides electric current via one or more batteries and controls release of electric current to the disposable cartridge using one or more electrical current delivery devices. Electrical connectors electrically connect the device to the disposable cartridge through a printed circuit board or a flex circuit, and the current delivery devices drive a precise electrical current profile to the foil substrate.
This configuration affects electrical resistive heating at a rate that achieves a precise temperature profile with a controllable ramp-up to a target temperature and heating rate. The temperature profile is suitable to vaporize a therapeutically effective amount of the alprazolam composition within 3 seconds or less, followed by condensation inside the cartridge to form alprazolam aerosol particles, while reducing thermal degradation products.
Claims Coverage
The independent claim covers a drug device configured to produce an alprazolam condensation aerosol using a disposable cartridge with an alprazolam-coated foil and a handheld device that delivers a precise resistive-heating temperature profile with rapid vaporization followed by condensation. Five inventive features are identified, with dependent claims refining battery constraints, cartridge recognition/verification, and temperature-control measurement modalities and heating-profile limitations.
Disposable cartridge with alprazolam-coated foil substrate for condensation aerosol
A disposable cartridge comprising an alprazolam composition coated on a foil substrate, where vapor is condensed inside the cartridge to form alprazolam aerosol particles.
Handheld airflow airway for cartridge-based condensation
A handheld medical device comprising one or more air inlets and one or more air outlets defining an airway, with at least one air outlet configured as a housing to attach the disposable cartridge.
Battery-driven precise electrical current delivery to foil resistive heating
One or more batteries provide electric current, and one or more electrical current delivery devices drive a precise electrical current profile to the foil substrate to affect electrical resistive heating at a rate that achieves a precise temperature profile with controllable ramp-up to a target temperature and heating rate.
Rapid vaporization within 3 seconds or less followed by condensation in the cartridge
The temperature profile is suitable to vaporize a therapeutically effective amount of the alprazolam composition coated on the foil substrate within a period of 3 seconds or less followed by condensation inside the cartridge of the resulting vapor to form alprazolam aerosol particles.
Electrical connection via printed circuit board or flex circuit
Connectors and the foil substrate are electrically connected through a printed circuit board or a flex circuit.
Overall, the claim coverage is directed to a handheld condensation-aerosol drug device using a disposable alprazolam-coated foil cartridge, where battery-powered precise electrical current delivery generates a controlled resistive-heating temperature profile that vaporizes within 3 seconds or less and enables condensation inside the cartridge to form aerosol particles.
Stated Advantages
Enables vaporization of a therapeutically effective amount of alprazolam composition within a period of 3 seconds or less followed by condensation inside the cartridge to form alprazolam aerosol particles.
Aims to reduce thermal degradation products while forming condensation aerosol particles, including specified MMAD particle sizing variants.
Documented Applications
Treatment via inhalation by producing an alprazolam condensation aerosol from a disposable cartridge using the described handheld medical device.
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