Methods, devices, and systems for detecting analytes
Inventors
LaLonde, John • Batten, Bruce Edgar
Assignees
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Publication Number
US-12208390-B2
Publication Date
2025-01-28
Expiration Date
Abstract
This document provides methods, devices, and systems for detecting the presence, absence, or amount of one or more analytes. For example, this document provides methods for using graphene-based sensors to detect one or more analytes (e.g., proteins, nucleic acids, intact cells, intact viruses, intact microorganisms, and/or chemicals).
Core Innovation
The multiplexed analyte detection system includes a sample application area for receiving a sample, a plurality of graphene sensors comprising channels connected to the sample application area, and an application specific integrated circuit (ASIC) electrically connected to graphene sensors of the plurality of graphene sensors comprising channels and configured to receive electrical signals from the graphene sensors.
The system measures analyte in a sample by applying the sample to the sample application area and by using the graphene sensors comprising channels connected to the sample application area, where the ASIC receives electrical signals from the graphene sensors.
The analyte is detected by detecting a change in resistance from the received electrical signals to detect whether the analyte is present in the sample, with the electrical signals produced by the graphene sensors in the plurality of channels received by the ASIC.
Claims Coverage
Across the independent claims, the coverage centers on a multiplexed graphene-sensor detection architecture using a sample application area, a plurality of graphene sensor channels, and an application specific integrated circuit (ASIC) electrically connected to receive electrical signals from the graphene sensors, with one independent claim explicitly reciting resistance-change detection of analyte presence.
Multiplexed analyte detection system architecture with graphene sensor channels and ASIC
A multiplexed analyte detection system with a sample application area for receiving a sample, a plurality of graphene sensors comprising channels connected to the sample application area, and an application specific integrated circuit (ASIC) electrically connected to graphene sensors of the plurality of graphene sensor comprising channels and configured to receive electrical signals from the graphene sensors.
Measuring an analyte in a sample using graphene sensor channels and ASIC
A system for measuring an analyte in a sample comprising a sample application area connected to a plurality of graphene sensors comprising channels and an application specific integrated circuit (ASIC) electrically connected to graphene sensors of the plurality of graphene sensors comprising channels.
Resistance-change detection of analyte presence using graphene sensors and ASIC
A method of detecting whether an analyte is present in a sample by applying the sample to a sample application area of a multiplexed analyte detection system comprising a plurality of graphene sensors comprising channels connected to the sample application area and an application specific integrated circuit (ASIC) electrically connected to graphene sensors in the plurality of channels and configured to receive electrical signals from the graphene sensors, and detecting a change in resistance from the received electrical signals to detect whether the analyte is present in the sample.
The independent claims collectively require a multiplexed graphene-sensor sensing architecture that uses a sample application area, multiple graphene sensor channels, and an ASIC to receive electrical signals, and at least one independent claim explicitly limits detection to measuring a change in resistance to determine analyte presence.
Stated Advantages
Documented Applications
No documented applications found
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