Medical analyzer and coagulation profiler with tracked oscillating disc
Inventors
Joseph, Luke B. • Hasling, Thomas A.
Assignees
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Publication Number
US-12203833-B1
Publication Date
2025-01-21
Expiration Date
Abstract
A medical analyzer and coagulation profiler performs various interrogations on specimens. A motor with reduction gearing moves and a video camera observes the samples, the cartridges or parts thereof. Changes in images are compared and recorded with a central processor that controls a display. Power supply, temperature controller, motor and gearing are mounted in a box which attaches to a smartphone. The smartphone provides the video camera, illumination and central processor that control the movement, temperature and display. The device makes testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and controls a number of parallel or serial devices operating simultaneously or sequentially. A cartridge insertion actuates a circular motion to generate a blood profile based on changes. Change is analyzed with a video camera and processor such as in a smartphone and is plotted to show an amplitude and time. A smartphone provides a specific movement pattern.
Core Innovation
The invention provides a handheld medical analyzer platform using a disposable coagulation profile cartridge that includes a biological microelectromechanical system (BioMEMS). A disc positioned in the well is placed in contact with whole blood and is rotated and oscillated using magnetic actuation, including rotation in a first direction and a second direction opposite the first direction.
Motion is captured by a smartphone video camera of tracking points on the disc. The disc includes a first tracking point at a rotational center and a second tracking point spaced apart from the rotational center, and the method captures motion of the second tracking point. In the fluorescent tracking implementation, the first point and second point are fluorescent when illuminated, with observation of the motion of the fluorescent tracking point.
A processor analyzes changes in motion of the tracking points to determine a coagulation profile. Angular motion is calculated by comparing a centroid of the first point to a centroid of the second point, where changes in the viscoelasticity of the sample as the sample coagulates changes the angular motion. The resulting coagulation profile is plotted over time using amplitude versus time parameters analogous to TEG, with real-time processing and/or continuous determination described.
Claims Coverage
The partial content includes three independent methods that share a common measurement concept: oscillating a disc in a well using a magnetic field and deriving a coagulation profile from captured motion. Across the independent claims, the inventive features include motion capture of a tracking point and processor-based profile determination, fluorescent illumination and tracking during observation, and centroid-based angular motion calculation that relates viscoelasticity changes to the computed coagulation profile.
Rotating an oscillating disc in a well using a magnetic field and determining a coagulation profile from tracking-point motion
Placing a sample into a well; rotating a disc positioned in the well using a magnetic field so the disc oscillates between rotating in a first direction and a second direction opposite the first direction; the disc includes a first tracking point at a rotational center and a second tracking point spaced apart from the rotational center; capturing motion of the second tracking point; and analyzing changes in motion of the second tracking point with a processor to determine a coagulation profile.
Fluorescent tracking points illuminated for observing disc motion and processor-based coagulation profiling
Rotating a disc positioned in a well using a magnetic field so the disc oscillates between opposite rotation directions; the disc includes a first tracking point at a rotational center and a second tracking point spaced apart from the rotational center; the first point and the second point are florescent when illuminated; observing motion of the second tracking point; and analyzing changes of motion with a processor to determine a coagulation profile.
Tracking two points and calculating angular motion via centroids to determine a coagulation profile from viscoelasticity changes
Rotating a disc relative to a sample using a magnetic field so the disc oscillates between rotating in a first direction and a second direction opposite the first direction; the disc includes a first tracking point at a rotational center and a second tracking point spaced apart from the rotational center; tracking the first point and the second point; and calculating angular motion by comparing a centroid of the first point to a centroid of the second point to determine a coagulation profile, wherein the viscoelasticity of the sample as the sample coagulates changes the angular motion.
Across the independent claims, the invention is covered by methods that oscillate a disc in a well using a magnetic field, capture motion using one or more tracking points, and compute a coagulation profile by processor analysis. The scope differentiates fluorescent tracking implementation and a centroid-comparison angular-motion approach tied to viscoelasticity changes during coagulation.
Stated Advantages
Repeatability across cartridges is reported.
Fibrin adhesion is described in relation to HDDA.
Documented Applications
Use in a handheld, smartphone-docked coagulation analyzer platform employing a disposable BioMEMS cartridge to measure coagulation and generate a coagulation profile over time.
Validation against control levels, including Haemoscope Level I control and Haemoscope Level II control.
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