Devices configured to provide treatment at an Abreu brain thermal tunnel
Inventors
Assignees
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Publication Number
US-12201796-B2
Publication Date
2025-01-21
Expiration Date
Abstract
Provided are devices for therapeutic interaction with an Abreu brain thermal tunnel (ABTT) terminus. Such devices are configured to provide one or more drugs to an ABTT terminus, and may provide heat to or remove heat from the ABTT terminus while providing the one or more drugs.
Core Innovation
A transdermal delivery device is provided that non-invasively delivers a drug by positioning a first portion on an Abreu brain thermal tunnel (ABTT) terminus and a second portion above a human eyebrow. The first portion and second portion are connected by a connection with a width less than the widths of the first and second portions, and the two-portion support is configured to establish a low-barrier, valveless vascular pathway associated with the ABTT to improve brain delivery via facial veins feeding the ABTT.
The device includes a first volume located on the first portion and an absorbent material positioned within the first volume, and a second volume located on the second portion containing a drug. A flow control membrane is positioned between the first volume and the second volume and is configured to control a rate of flow of the drug from the second volume to the first volume, and a removable layer is positioned as an outermost layer on at least the first portion and is configured to expose only the first volume at removal from the first portion.
Another transdermal delivery device configuration uses layered components including a spacer layer, a cover layer, an adhesive layer, and a removable layer on the adhesive layer. A flow control membrane is positioned between the support and the cover layer and protrudes into both the cover layer and the support, with a plug positioned between the support and the cover layer. The structure forms a first volume containing an arrangement of the layered components while a second volume contains a liquid drug, where the first and second volumes enable controlled delivery toward the ABTT terminus.
Claims Coverage
The partial set contains two independent claims. Across the two independent claims, the main inventive features include a two-portion support layout relative to an ABTT terminus and an eyebrow, volume-and-membrane-controlled drug transport, removable-layer exposure of the ABTT-contacting volume, and layered support/adhesive/membrane/plug structures in the second claim.
Two-portion support for ABTT terminus and eyebrow connection
The device includes a support having a first portion configured to be positioned on an Abreu brain thermal tunnel (ABTT) terminus, a second portion configured to be positioned above a human eyebrow, and a connection positioned between the first portion and the second portion, where the width of the connection is less than a width of the first portion and a width of the second portion.
First and second volumes with absorbent material and drug
The device includes a first volume located on the first portion with an absorbent material positioned within the first volume, and a second volume located on the second portion with a drug located within at least the second volume.
Flow control membrane controlling drug flow between volumes
A flow control membrane is positioned between the first volume and the second volume, and the flow control membrane is configured to control a rate of flow of the drug from the second volume to the first volume.
Removable outermost layer exposing only the first volume
A removable layer is positioned as an outermost layer on at least the first portion, and the removable layer is configured to expose only the first volume at removal of the removable layer from the first portion.
Layered support with adhesive and removable layer plus membrane protrusion
The device includes a support with a first portion configured to be positioned on an Abreu brain thermal tunnel (ABTT) terminus and a second portion configured to be positioned above a human eyebrow, a spacer layer positioned on the support, a cover layer positioned on the spacer layer, an adhesive layer positioned on the cover layer, and a removable layer positioned on the adhesive layer.
Protruding flow control membrane and plug forming first/second volumes
A flow control membrane is positioned between the support and the cover layer, the flow control membrane is configured to protrude into the cover layer and into the support, and a plug is positioned between the support and the cover layer; a first volume is formed by the support, the spacer layer, the cover layer, the removable layer, and the flow control membrane, and a second volume is formed by the support, the spacer layer, the cover layer, the flow control membrane, and the plug, with the second volume containing a liquid drug.
Both independent claims center on transdermal delivery to an ABTT terminus using a two-portion support layout, controlled drug transport via a flow control membrane between defined volumes, and removable-layer configurations that expose the ABTT-contacting volume, with the second independent claim additionally requiring layered support including adhesive/removable layers plus a protruding membrane and a plug to form a liquid-drug second volume.
Stated Advantages
Improved brain delivery via a low-barrier, valveless vascular pathway associated with the ABTT terminus.
Documented Applications
Non-invasive transdermal drug delivery targeting the Abreu brain thermal tunnel (ABTT) terminus, using device arrangements positioned on an ABTT terminus and above a human eyebrow.
Delivery configurations include passive patch/interface concepts and active systems with heating/cooling controlled by sensors/controllers, as documented in the provided description.
Monitoring/closed-loop drug detection concepts are described, including tear-based drug detection.
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