Implants having bone growth promoting agents contained within biodegradable materials
Inventors
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12201531-B2
Publication Date
2025-01-21
Expiration Date
Abstract
Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants may include biodegradable polymer particles contained within biocompatible fibers. The biodegradable polymer particles may include bone growth promoting agents that are released as the particles degrade over time.
Core Innovation
The invention relates to an implant for interfacing with a bone structure. The implant includes a web structure comprising a plurality of struts joined at nodes, where the web structure is configured to interface with human bone tissue.
The implant further includes a mixture of biodegradable material coating at least a portion of the struts contained in the web structure. The biodegradable material is configured to degrade over time in the presence of biological fluids in order to release a first bone growth promoting agent encapsulated within the biodegradable material.
In addition, the implant includes a plurality of non-degradable biocompatible fibers contained within the web structure, and a plurality of biodegradable particles contained within the non-degradable biocompatible fibers. The biodegradable particles encapsulate a second bone growth promoting agent, and the biodegradable particles dissolve in the presence of biological fluids to release the encapsulated second bone growth promoting agent.
The description also ties the web structure to biologic delivery intended to promote bone fusion, and associates web-induced microstrain and osteoblast BMP production with faster healing. The implant can use a space-truss web formed from multiple planar truss units for mechanical support and increased surface area to promote fusion, while biodegradable components degrade in biological fluids to release bone-growth promoting agents.
Claims Coverage
The independent claim covers an implant interfacing with human bone tissue that combines a strut/node web structure with two distinct degradable delivery components: a biodegradable coating on struts releasing a first bone growth promoting agent, and non-degradable biocompatible fibers carrying biodegradable particles releasing a second bone growth promoting agent. The claim includes inventive features related to the web structure configuration and the two-stage bone growth agent release architecture.
Strut/node web structure configured to interface with human bone tissue
A web structure comprising a plurality of struts joined at nodes, wherein the web structure is configured to interface with human bone tissue.
Biodegradable material coating on struts releasing a first bone growth promoting agent
A mixture of biodegradable material coating at least a portion of the struts contained in the web structure, wherein the biodegradable material is configured to degrade over time in a presence of biological fluids in order to release a first bone growth promoting agent encapsulated within the biodegradable material.
Non-degradable biocompatible fibers containing biodegradable particles releasing a second bone growth promoting agent
A plurality of non-degradable biocompatible fibers contained within the web structure; and a plurality of biodegradable particles contained within the non-degradable biocompatible fibers, wherein the biodegradable particles encapsulate a second bone growth promoting agent, and wherein the biodegradable particles dissolve in the presence of biological fluids in order to release the encapsulated second bone growth promoting agent.
Overall, the claim coverage is anchored on an implant that uses a strut/node web structure and provides two degradable release mechanisms: a biodegradable coating on struts releasing a first encapsulated bone growth promoting agent, and biodegradable particles within non-degradable biocompatible fibers releasing a second encapsulated bone growth promoting agent in the presence of biological fluids.
Stated Advantages
Promotes fusion by providing mechanical support and increased surface area through the web structure.
Associates faster healing with web-induced microstrain and osteoblast BMP production.
Enables biologic delivery by releasing bone-growth promoting agents as biodegradable components degrade or dissolve in biological fluids.
Documented Applications
An implant for interfacing with a bone structure, including interface with human bone tissue.
Use in bone fusion promotion and faster healing associated with osteoblast BMP production and microstrain induced by the web structure.
Interested in licensing this patent?