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Publication Number
US-12194457-B2
Publication Date
2025-01-14
Expiration Date
Abstract
Described herein is a device for collecting plasma from a blood sample, the device comprising a body defining a flow channel extending between a proximal and a distal end, the flow channel comprising: a membrane region for supporting a separation membrane that filters red blood cells from the plasma; a plasma collection region for supporting an absorbent membrane that collects the plasma; and a chamber for separating the membrane region from the plasma collection region.
Core Innovation
The invention provides a device for collecting plasma from a blood sample that defines a laterally extending flow channel between a proximal and a distal end. The flow channel includes a membrane region with a separation membrane for filtering red blood cells from the plasma, a plasma collection region with an absorbent membrane for collecting the plasma, and a flow path region upstream of the membrane region.
The device is configured so that flow of the plasma from the separation membrane to the absorbent membrane is impedable. The separation membrane and the absorbent membrane do not touch, and a chamber separates the membrane region from the plasma collection region, enabling blocking plasma flow after plasma is collected and supporting a one-step plasma collection approach.
The described embodiments include removably coupled device regions without adhesive coupling and provide structural features such as a handle and a window for visual inspection and/or drying. The device includes a proximal vent for defined plasma volume in a chamber embodiment and may include mobilizable colorants associated with a plasma front for quality control.
Claims Coverage
Independent claim clm-00001 contains 2 main inventive claim aspects, with additional optional/constraint refinements introduced in dependent claims.
Lateral flow channel with separated membrane region and plasma collection region
A device for collecting plasma from a blood sample having a body defining a flow channel extending laterally between a proximal and a distal end, the flow channel comprising a membrane region with a separation membrane for filtering red blood cells from the plasma, a plasma collection region with an absorbent membrane for collecting the plasma, and a flow path region upstream of the membrane region.
Chamber-separated, impedable plasma flow with non-touch membranes
A chamber for separating the membrane region from the plasma collection region wherein flow of the plasma from the separation membrane to the absorbent membrane is impedable, and wherein the separation membrane and the absorbent membrane do not touch one another.
Overall claim coverage focuses on a lateral plasma collection flow channel that uses a separation membrane and an absorbent membrane separated by a chamber, with plasma flow impeded between the membranes while preventing membrane-to-membrane contact.
Stated Advantages
Blocks plasma flow after plasma is collected.
Provides one-step plasma collection.
Supports avoiding substantial hemolysis by using separation membrane pore-size constraints.
Enables visual inspection and/or quality control of plasma front using a mobilizable colorant.
Allows plasma collection without buffer or diluent requirements (in dependent embodiments).
Allows embodiments without anticoagulant requirements (in dependent embodiments).
Documented Applications
Collecting plasma from a blood sample for analyte quantitation from plasma.
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