Topical composition comprised of cod liver oil for treating wounds and skin disorders
Inventors
Bettle, III, Griscom • Harlin, John • Gardner, Thomas
Assignees
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Publication Number
US-12186346-B2
Publication Date
2025-01-07
Expiration Date
Abstract
Disclosed is a topical anhydrous, homogenous pharmaceutical composition for treating skin disorder and wounds comprising cod liver oil, hempseed oil, monolaurin, medium chain triglycerides (“MCT”), free fatty acids, sea salt, and vegetable oil selected from the group consisting of red palm concentrate, coconut oil, and red palm oil and combination thereof and optionally fish collagen, ascorbyl palmitate, thickening agent, such as beeswax, red palm concentrate and cetyl ester.
Core Innovation
The invention relates to an anhydrous topical composition comprising an omega fatty acid product and fish collagen. The omega fatty acid product includes cod liver oil and hempseed oil, together with a thickening agent and ascorbyl palmitate, and the sum of the cod liver oil and the fish collagen comprises at least 50% of the omega fatty acid product by weight. The omega fatty acid product comprises at least two melting point temperatures.
The fish collagen is incorporated with the omega fatty acid product such that the ascorbyl palmitate is sterically hindered from entering the fish collagen and precipitates on an outer surface of the fish collagen. After the thickening agent and the ascorbyl palmitate are incorporated within the omega fatty acid product, the combination of the thickening agent and the ascorbyl palmitate inhibits the cod liver oil, the hempseed oil, or both from seeping from the fish collagen.
The disclosure addresses oil weeping or oil seepage from fish collagen in topical compositions, including under temperature stress, and issues associated with cod liver oil and hempseed oil formulations such as rancid fish smell. It emphasizes pore plugging and seepage prevention via melting point behavior of the omega fatty acid product and outer-surface precipitation behavior of sterically hindered ascorbyl palmitate on fish collagen.
Claims Coverage
The relevant claims include one independent claim. The independent claim centers on an anhydrous omega fatty acid product formulation containing cod liver oil, hempseed oil, fish collagen, thickening agent, and sterically hindered ascorbyl palmitate, with specified melting-point behavior and a mechanism for inhibiting oil seepage from fish collagen.
Sterically hindered ascorbyl palmitate precipitating on outer surface of fish collagen
The omega fatty acid product includes fish collagen, and ascorbyl palmitate is sterically hindered from entering the fish collagen whereby the ascorbyl palmitate precipitates on an outer surface of the fish collagen.
Seepage inhibition by thickening agent and ascorbyl palmitate
After the thickening agent and the ascorbyl palmitate are incorporated within the omega fatty acid product, a combination of the thickening agent and ascorbyl palmitate inhibits the cod liver oil, the hempseed oil, or both from seeping from the fish collagen.
Anhydrous omega fatty acid product formulation with cod liver oil, hempseed oil, thickening agent, and ascorbyl palmitate
An anhydrous topical composition comprising an omega fatty acid product in which the omega fatty acid product comprises about 5% to about 30% cod liver oil by weight, about 10% to about 30% hempseed oil by weight, about 2% to about 8% thickening agent by weight, about 0.3% to about 0.6% ascorbyl palmitate by weight, and a fish collagen, wherein the sum of the cod liver oil and the fish collagen comprises at least 50% of the omega fatty acid product by weight.
Omega fatty acid product with at least two melting point temperatures
The omega fatty acid product comprises at least two melting point temperatures.
Overall, the independent claim requires an anhydrous topical composition having a defined omega fatty acid product composition, multiple melting point temperatures, and a containment/seepage inhibition mechanism based on sterically hindered ascorbyl palmitate precipitating on an outer surface of fish collagen together with thickening agent.
Stated Advantages
Inhibits cod liver oil, hempseed oil, or both from seeping from the fish collagen.
Enables pore plugging and seepage prevention in formulations using fish collagen and sterically hindered ascorbyl palmitate precipitation behavior.
Reduces oil weeping under heat stress.
Reduces or eliminates rancid fish smell.
Provides antibacterial/biofilm reduction in ex vivo porcine wound biofilm models as described in the disclosure content.
Documented Applications
Topical treatment for wounds and skin disorders, including use with hydrocolloid bandage application as described.
Use in ex vivo porcine skin wound biofilm models, with reduction of biofilm as described.
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