Respiratory delivery device
Inventors
Trout, Benjamin Barnaby • Farquhar, Lachlan David • Lynch, Patrick Joseph • Fredatovich, John
Assignees
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Publication Number
US-12171934-B2
Publication Date
2024-12-24
Expiration Date
Abstract
The present disclosure provides for a respiratory delivery device. Particularly, the disclosure provides for a delivery device for use in administering a particulate medicament to a subject's airway and lungs via inhalation. The delivery device may be suitable for emergency medicine for the delivery of active pharmaceutical ingredients including epinephrine.
Core Innovation
The disclosure describes a respiratory, dry powder inhalation delivery device for delivery of a composition to an airway of a subject. The device has a body defined about a central axis and includes a composition receptacle adapted to receive a composition capsule containing the composition, including emergency epinephrine, adjacent to a dispersion chamber defined by at least one wall with two openings therein, and a gas outlet.
External gas enters the device through two gas inlets adjacent the dispersion chamber and defining an inlet gas axis extending substantially perpendicular to the central axis. Each opening is continuous with a respective flow inlet path defined between an outer flow inlet path wall continuous with the dispersion chamber wall and an inner flow inlet path wall, and the at least one wall defines a distal end adjacent the composition receptacle and a proximal end closer to the gas outlet.
The geometry of the inlet/dispersion interaction is defined such that the flow inlet paths extend in a plane perpendicular to the central axis between the gas inlets and the two openings, taper to form a point of maximum constriction located adjacent the respective openings, and decrease in cross-sectional area on moving from the respective gas inlet toward the respective opening. In a dry powder inhaler embodiment, the flow inlet paths further extend at between a 30 to 50 degree angle to the gas inlet axis, and in some embodiments present a slope having an angle between about 30 to about 45 degrees as measured relative to the dispersion chamber at the point of entry.
The device may include capsule piercing features with one or more primers and a cap, where the cap engages and displaces the primers to pierce a composition capsule when the cap is removed. The disclosure also includes an optional deagglomerator positioned adjacent to the dispersion chamber between the dispersion chamber and the gas outlet, and safety or anti-reuse features in the sealed gas flow path context.
Claims Coverage
The partial content identifies three independent claims directed to a device architecture for airway delivery using a capsule receptacle, a two-opening dispersion chamber, and a constrained pair of gas inlets/flow inlet paths with a perpendicular inlet gas axis relationship and tapering to maximum constriction; the independent set includes one general device claim and two dry powder inhaler device claims with additional angular and slope constraints.
Central-body inhalation delivery with two openings and adjacent receptacle
A device for delivery of a composition to an airway of a subject having a body defined about a central axis and comprising a composition receptacle adapted to receive a composition capsule containing the composition, a dispersion chamber defined by at least one wall comprising two openings and located adjacent the composition receptacle, and a gas outlet, wherein the two openings are each continuous with a respective flow inlet path and gas external to the device enters via the flow inlet paths and gas inlets adjacent the dispersion chamber.
Perpendicular inlet gas axis defined by gas inlet passage adjacent dispersion chamber
The gas inlets form a passage through the body of the device adjacent the dispersion chamber to define an inlet gas axis extending substantially perpendicular to the central axis, the central axis passing through a portion of the first and second ends of each respective gas inlet.
Dispersion chamber planes overlap region and flow inlet paths confined between planes
The at least one wall of the dispersion chamber has a distal end adjacent the composition receptacle defining a first plane and a proximal end closer to the gas outlet than the distal end defining a second plane, wherein each gas inlet is formed in a region of the body overlapping a region formed between the first and second planes, and wherein the flow inlet paths extend in a plane perpendicularly to the central axis between the gas inlets and the two openings.
Tapered flow inlet paths with maximum constriction adjacent openings
The flow inlet paths taper to form at least one point of maximum constriction located adjacent the respective openings in the at least one wall of the dispersion chamber and a cross-sectional area of each flow inlet path decreases on moving from the respective gas inlet in a direction of the respective opening.
Dry powder inhaler with spaced exterior walls and constrained flow inlet angle to gas inlet axis
A dry powder inhaler device having a body defined about a central axis comprising a composition receptacle, an adjacent dispersion chamber with two openings, and a gas outlet, wherein an exterior of the body comprises a first wall and a second wall spaced apart to create two spaced regions and the gas inlets are formed in the respective spaced region, the flow inlet paths extend in a plane perpendicularly to the central axis between the gas inlets and the two openings, and the flow inlet paths extend at between a 30 to 50 degree angle to the gas inlet axis.
Dry powder inhaler with tapering to maximum constriction and confinement by dispersion-chamber planes
The dry powder inhaler device wherein a cross-sectional area of each flow inlet path decreases on moving from the respective gas inlet toward the respective opening, the flow inlet paths taper to form at least one point of maximum constriction adjacent the respective openings, and the at least one wall of the dispersion chamber defines first and second planes with the gas inlets overlapping a region between the first and second planes and the flow inlet paths located only between the first and second planes.
Dry powder inhaler with flow inlet slope angle relative to dispersion chamber wall at entry
A dry powder inhaler device having the flow inlet paths present a slope having an angle of between about 30 to about 50 degrees as measured relative to the dispersion chamber at the point of entry to the dispersion chamber.
Across the independent claims, the core claim coverage centers on a respiratory dry powder inhalation delivery device architecture in which two gas inlets pass through a body region adjacent a two-opening dispersion chamber to define an inlet gas axis substantially perpendicular to the central axis, with flow inlet paths that extend perpendicularly to the central axis, taper to maximum constriction adjacent the openings, decrease in cross-sectional area toward the openings, and are further geometrically constrained by dispersion chamber planes and specified angle/slope ranges in the dry powder inhaler independent claims.
Stated Advantages
Improved fine particle output and reduced in-device build-up compared with an RS01 DPI, supporting improved deep-lung delivery.
Improved usability across varying lung functions.
Documented Applications
Delivery of a composition to an airway of a subject by inhalation using a dry powder inhaler device, including emergency epinephrine.
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