Methods, systems, and apparatus for closed-loop neuromodulation
Inventors
OPIE, Nicholas Lachlan • Oxley, Thomas James • RIND, Gil Simon
Assignees
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Publication Number
US-12168135-B2
Publication Date
2024-12-17
Expiration Date
Abstract
Systems, apparatus, and methods for treating medication refractory epilepsy are disclosed. In one embodiment, a method of treating epilepsy is disclosed comprising detecting, using a first electrode array coupled to a first endovascular carrier, an electrophysiological signal of a subject. The method further comprises analyzing the electrophysiological signal using a neuromodulation unit electrically coupled to the first electrode array and stimulating an intracorporeal target of the subject using a second electrode array coupled to a second endovascular carrier implanted within a part of a bodily vessel superior to a base of the skull of the subject.
Core Innovation
Not explicitly described in patent.
Not explicitly described in patent.
Claims Coverage
The partial content provides one independent claim (clm-00001), describing a closed-loop method for treating epilepsy using endovascular electrode arrays and an implanted neuromodulation unit with responsive stimulation.
Endovascular detection and implanted neuromodulation analysis
Detecting, using a first electrode array, an electrophysiological signal of a subject, wherein the first electrode array is coupled to a first endovascular carrier implanted within the subject in at least one of a superior sagittal sinus, an inferior sagittal sinus, a sigmoid sinus, a transverse sinus, and a straight sinus; analyzing the electrophysiological signal using a neuromodulation unit implanted within the subject and electrically coupled to the first electrode array.
Responsive endovascular stimulation of an intracorporeal target
Stimulating an intracorporeal target of the subject using a second electrode array in response to the electrophysiological signal detected, wherein the second electrode array is electrically coupled to the neuromodulation unit, and wherein the second electrode array is coupled to a second endovascular carrier implanted within at least one of a vein of Labbe, a vein of Trolard, a Sylvian vein, and a Rolandic vein of the subject.
Across the independent claim, the inventive concept is a closed-loop workflow that detects an electrophysiological signal via a first electrode array on an implanted endovascular carrier, analyzes it with an implanted neuromodulation unit, and triggers stimulation via a second electrode array on a second implanted endovascular carrier targeting an intracorporeal target.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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