Method and system for quantifying movement disorder symptoms
Inventors
Heldman, Dustin A. • Giuffrida, Joseph P.
Assignees
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Publication Number
US-12161478-B1
Publication Date
2024-12-10
Expiration Date
Abstract
A system and method for scoring movement disorder symptoms comprises a movement measurement data acquisition system and processing comprising kinematic feature extraction and an algorithm trained using Unified Parkinson's Disease Rating Scale (UPDRS) scores from skilled clinicians. The movement data acquisition system, or “movement measuring apparatus,” may comprise sensors such as accelerometers or gyroscopes or may utilize motion capture and/or machine vision technology or various other methods to measure tremor, bradykinesia, dyskinesia, or other movement disorders in a subject afflicted with Parkinson's disease, essential tremor or the like. The method outputs, and system displays, a score that uses the same scale as the UPDRS but has greater resolution and lower variability. In some embodiments, the system is used to diagnose and/or treat the patient by providing recommendations for treatment and/or by supplying treatment in the form of pharmaceutical drugs and/or electric stimulus as part of a closed-loop system.
Core Innovation
The invention provides a system and method for quantifying symptoms of a movement disorder in a subject. The system includes a movement measuring apparatus with a sensor unit having four or fewer sensors, including at least one accelerometer and at least one gyroscope, adapted to acquire movement data while the subject performs at least one motor exam test. The movement measuring apparatus is adapted to be worn or attached on an upper extremity, and the test is prescribed or instructed by a clinician.
A processor processes the acquired movement data to extract at least two different kinematic features related to severity of at least one movement disorder symptom related to the motor exam test. The processor calculates a score representative of severity based at least in part on the at least two kinematic features and on reference data that includes clinician-assigned motor test scores.
The processor output comprises the calculated score and/or treatment recommendations based at least in part on the calculated score. The system further provides a treatment delivery device adapted to receive the processor output and to provide treatment based at least in part on the calculated score and/or treatment recommendations, including providing treatment using a drug delivery system and/or a deep brain stimulation device.
Claims Coverage
The document contains three independent claims that cover a clinician-prescribed upper-extremity wearable sensing setup with accelerometer(s) and gyroscope(s), extraction of at least two different kinematic features, calculation of a severity score using reference data including clinician-assigned motor test scores, and use of the score and/or treatment recommendations by a treatment delivery device. The third independent claim further requires that at least one kinematic feature is directed to a measure other than magnitude of the sensor signal.
Upper-extremity wearable movement measuring with limited multi-sensor unit
A movement measuring apparatus comprising a sensor unit comprising four or fewer sensors, including at least one accelerometer and at least one gyroscope, adapted to acquire movement data while the subject performs at least one motor exam test prescribed or instructed by a clinician, and adapted to be worn or attached on an upper extremity.
Severity score calculation from kinematic features and clinician reference scores
A processor adapted to process the acquired movement data to extract at least two different kinematic features related to severity of at least one movement disorder symptom related to the motor exam test, and to calculate a score representative of severity based at least in part on the at least two kinematic features and on reference data that includes clinician-assigned motor test scores.
Processor output used for treatment by a treatment delivery device
A processor output comprising the calculated score and/or treatment recommendations based at least in part on the calculated score; and a treatment delivery device adapted to receive the processor output and to provide treatment to the subject based at least in part on the calculated score and/or treatment recommendations.
Non-magnitude-directed kinematic feature in severity scoring
At least one of the at least two different kinematic features is directed to a measure other than magnitude of the sensor signal.
Across the independent claims, the core coverage is a clinician-prescribed upper-extremity wearable sensing setup, extraction of at least two different kinematic features, calculation of a severity score using clinician-assigned motor test scores as reference data, and use of the score and/or treatment recommendations by a treatment delivery device. One claim further requires that at least one kinematic feature is directed to a measure other than magnitude of the sensor signal.
Stated Advantages
Provides a real-valued score representative of severity based on kinematic features and clinician-assigned motor test scores.
Uses the calculated score and/or treatment recommendations to provide treatment and to adjust treatment parameters with a treatment delivery device.
Documented Applications
Diagnosing and treating a subject having a movement disorder by prescribing or instructing motor exam tests, calculating a severity score from clinician-referenced kinematic features, and using the score for treatment delivery.
Treatment provision based on the calculated score, including treatment via a drug delivery system and/or deep brain stimulation device.
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