Foam compositions, foam matrices and methods
Inventors
Dudnyk, Vyacheslav • KANOATOV, Mirzo • DiTizio, Valerio
Assignees
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Publication Number
US-12151033-B2
Publication Date
2024-11-26
Expiration Date
Abstract
Disclosed herein are matrices, compositions and methods of making matrices. The matrix comprises a biomolecule and the matrix is a dried, cross-linked foam. The matrix is not lyophilized. The method comprises foaming the composition, crosslinking the composition and drying the composition. Matrices disclosed herein are useful as wound dressings and treating wounds.
Core Innovation
The invention provides a method for making a matrix by foaming a composition comprising a biomolecule and a biocompatible polymer. The biomolecule is selected from gelatin, collagen, elastin, and combinations thereof, and the biocompatible polymer is selected from polyethylene glycol, poly-L-lysine, alginate, chitosan, hyaluronic acid, chondroitin sulfate, pectin, cellulose, carboxymethylcellulose, and mixtures thereof. The method crosslinks the foamed composition and then dries it to prepare the matrix.
The matrix produced by the method is a dried, cross-linked foam that is non-lyophilized. The biomolecule and biocompatible polymer are evenly distributed throughout the matrix, and the biomolecule is present in an amount of about 40% to about 80% (w/w) by the weight of the matrix. The matrix has an absorption capacity of about 20 times to about 50 times a dry weight of the matrix.
Additional embodiments specify crosslinking using selected crosslinking agent(s) and may include structural constraints and antimicrobial active-agent embodiments, including silver ions from selected silver salts. The document also states wound care embodiments, including wound dressing, wound barrier, and hemostatic dressing embodiments.
Claims Coverage
The document provides one independent claim for making a dried, cross-linked, non-lyophilized foam matrix and dependent refinements that add specific crosslinking choices, polymer loading ranges, structural constraints, crosslinking timing constraints, and antimicrobial silver-ion embodiments. The independent claim contains 4 main inventive requirements: foaming a biomolecule/biocompatible polymer composition, crosslinking, drying to form a dried, cross-linked foam, and requiring even distribution, non-lyophilization, biomolecule loading, and high absorption capacity.
Foaming a biomolecule and biocompatible polymer composition
Foaming a composition comprising a biomolecule selected from gelatin, collagen, elastin, and combinations thereof, and a biocompatible polymer selected from polyethylene glycol, poly-L-lysine, alginate, chitosan, hyaluronic acid, chondroitin sulfate, pectin, cellulose, carboxymethylcellulose and mixtures thereof.
Crosslinking the foamed composition
Crosslinking the foamed composition.
Drying to prepare a dried, cross-linked foam matrix
Drying the composition to prepare the matrix, wherein the matrix is a dried, cross-linked foam and is non-lyophilized.
Even distribution with defined biomolecule amount and absorption capacity
The biomolecule and biocompatible polymer are evenly distributed throughout the matrix, wherein the biomolecule is present in an amount of from about 40% to about 80% (w/w) by the weight of said matrix, and wherein the matrix has an absorption capacity of from about 20 times to about 50 times a dry weight of the matrix.
Overall claim coverage centers on producing a dried, cross-linked, non-lyophilized foam matrix by foaming a defined biomolecule/biocompatible polymer composition, crosslinking, and drying, with even distribution plus specified biomolecule loading and high absorption capacity. Dependent claims further narrow crosslinking agents, polymer embodiments, structural constraints, timing of crosslinking relative to foaming, and antimicrobial embodiments using silver ions from selected silver salts.
Stated Advantages
High absorption capacity, defined as about 20 times to about 50 times a dry weight of the matrix.
Even distribution of the biomolecule and biocompatible polymer throughout the matrix.
Non-lyophilized dried, cross-linked foam matrix.
Antimicrobial action through reducing microorganism growth, including antimicrobial agents comprising silver ions from specified silver salts.
Documented Applications
Wound care as a wound dressing/covering, including wound barrier and hemostatic dressing embodiments.
Reducing microorganism growth on wounds, including antimicrobial performance.
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