EEG curve fitting to specify stimulation parameter
Inventors
Phillips, James William • Isenhart, Robert • Ring, Alexander
Assignees
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Publication Number
US-12144988-B2
Publication Date
2024-11-19
Expiration Date
Abstract
A method and system is provided for administering a Repetitive Transcranial Magnetic Stimulation (rTMS) or Transcranial Alternating Current Stimulation (tACS) at a pulse interval of is set equal to the period of a curve that best fits a section of a person's electroencephalogram (EEG) recorded before the pulse train.
Core Innovation
The invention relates to modulating activity of a brain of a subject by receiving an EEG signal from the subject during a first time interval that is selected to capture a transient change in an intrinsic frequency of the EEG signal. A curve is then fit to approximate a section of the EEG signal, where the fitted curve comprises more than one frequency and approximates the transient change in the intrinsic frequency of the EEG signal.
Repetitive pulses are determined using a pulse interval as a period of oscillation of the fitted curve. The repetitive pulses are applied to the brain at the pulse interval for a second time interval, where application begins within a third time interval less than or equal to the first time interval.
In a related aspect, repetitive pulses are determined using a variable pulse interval as an approximation of pulse intervals between adjacent and sequential oscillations of the fitted curve approximating the section of the EEG signal, and the repetitive pulses are applied at the variable pulse interval for a second time interval. In an apparatus aspect, electrodes receive the EEG signal, processors fit a parametric curve and determine repetitive pulses using a pulse interval as a period of oscillation, and a generator applies the repetitive pulses at the pulse interval within a third time interval that is less than or equal to the first time interval.
Claims Coverage
The provided material includes three independent claims. Across these independent claims, the core inventive features are linked to capturing a transient intrinsic-frequency change in EEG, fitting a multi-frequency (parametric) curve to the EEG section, and deriving stimulation pulse timing from the fitted curve oscillation interval, including time-window constraints for when stimulation begins.
Transient intrinsic-frequency capture by EEG time interval
Receiving an EEG signal from a subject during a first time interval selected to capture a transient change in an intrinsic frequency of the EEG signal.
Multi-frequency curve fitting to approximate transient intrinsic-frequency change
Fitting a curve to approximate a section of the EEG signal, wherein the fitted curve comprises more than one frequency and the fitted curve approximates the transient change in the intrinsic frequency of the EEG signal.
Pulse interval derived from fitted-curve oscillation for repetitive pulses
Determining repetitive pulses using a pulse interval as a period of oscillation of the fitted curve.
Timed application of repetitive pulses within EEG-derived time windows
Applying the repetitive pulses to the brain of the subject at the pulse interval for a second time interval, wherein application of the repetitive pulses begins within a third time interval that is less than or equal to the first time interval.
Variable pulse interval from adjacent sequential oscillations of the fitted curve
Determining repetitive pulses using a variable pulse interval as an approximation of pulse intervals between adjacent and sequential oscillations of the fitted curve approximating the section of the EEG signal.
Apparatus with EEG electrodes, curve fitting processors, and pulse generator timing
Including electrodes operable to receive an EEG signal for a first time interval, one or more processors to fit a parametric curve and determine repetitive pulses using a pulse interval as a period of oscillation, and a generator operable to apply the repetitive pulses at the pulse interval for a second time interval, wherein application occurs within a third time interval that is less than or equal to the first time interval.
Across the independent claims, the inventive coverage centers on EEG-driven transient intrinsic-frequency modeling via a multi-frequency (parametric) fitted curve and using that fitted curve’s oscillation interval to set stimulation pulse timing, including constant interval or variable interval between adjacent oscillations, with stimulation timing constrained to begin within a specified relationship to the EEG capture interval.
Stated Advantages
Documented Applications
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