Methods and apparatuses for central venous pressure measurement status
Inventors
Robinson, Mark Ries • Allen, Elena A • Salehpour, Fahimeh
Assignees
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Publication Number
US-12144596-B2
Publication Date
2024-11-19
Expiration Date
Abstract
Method and systems are provided for reliable, convenient, self-administered, and cost-effective determination of central venous pressure. The noninvasive method and apparatus use changes in transmural pressure to create detectable changes in peripheral venous vascular volume for the determination of central venous pressure. Transmural pressure changes can be manifested by intravascular or extravascular pressure changes. The system is noninvasive and uses optical measurements of venous volume in the presence of transmural pressure changes. The relationship between the transmural pressure change and the change in vascular venous volume is combined with anatomical measurements to determine the central venous pressure of the subject. Central venous pressure can be used to determine hemodynamic status of the subject to include fluid overload in the heart failure patient.
Core Innovation
The disclosure provides an apparatus for determining central venous pressure of an individual by varying a transmural pressure in one or more veins in a limb and assessing changes in the venous volume of the one or more veins as the pressure varies. A control system executes a measurement protocol that applies a plurality of transmural pressures including periodic modulation and systematic variance, and an analysis system determines the point of venous collapse and the transmural pressure at which the venous collapse occurs based on the venous volume changes.
To translate the collapse pressure into a central venous pressure value, the apparatus includes a height information system that determines a vertical separation between the one or more veins in the limb and the individual's heart. A central venous pressure determination system determines the central venous pressure responsive to both the transmural pressure at which venous collapse occurs and the vertical separation.
A further aspect of the disclosure is an alternative apparatus configuration in which an optical measurement system determines a measure of blood volume at each of a plurality of transmural pressures while a pressure mechanism varies transmural pressure in one or more veins of a limb. In that configuration, the height information system determines a height of the measurement region relative to an anatomical reference point, and an analysis system determines the central venous pressure from the determined height and from the relationship between transmural pressure and blood volume. The disclosed method version similarly subjects a limb measurement region to transmural pressures defined by a pressure profile, determines venous volume or volume change at the transmural pressures, identifies venous collapse and its transmural pressure, and determines central venous pressure from the collapse pressure and a vertical separation between the heart and the measurement region.
Claims Coverage
Independent claim coverage is provided by three independent claims. Collectively, the independent claims require varying transmural pressure in limb veins, determining pressure-dependent venous volume or blood volume behavior, and converting a collapse-related or relationship-based pressure measure into central venous pressure using vertical separation or height information.
Venous collapse determination with transmural-pressure modulation and height-based conversion
An apparatus determining central venous pressure by varying a transmural pressure in one or more veins in a limb using a pressure management system executing a measurement protocol with a plurality of transmural pressures including periodic modulation and systematic variance, assessing venous volume changes as transmural pressure varies, determining a point of venous collapse and the transmural pressure at which the venous collapse occurs, determining a vertical separation between the one or more veins and the individual's heart, and determining central venous pressure responsive to the transmural pressure at which venous collapse occurs and the vertical separation.
Optical blood-volume determination across transmural pressures with height-relative analysis
An apparatus comprising a pressure mechanism to vary a transmural pressure in one or more veins of a limb, an optical measurement system responsive to venous blood presence in a measurement region configured to determine a measure of blood volume at each of a plurality of transmural pressures, a height information system configured to determine a height of the measurement region relative to an anatomical reference point, and an analysis system configured to determine the central venous pressure from the determined height and from the relationship between the transmural pressure and the blood volume.
Method using venous collapse from transmural-pressure profile and heart-to-measurement vertical separation
A method for determining central venous pressure comprising subjecting a measurement region of a limb to a plurality of transmural pressures as defined by a pressure profile, determining an indication of a volume of one or more veins at each of the plurality of transmural pressures or a change in the volume between pairs of the plurality of transmural pressures or a combination thereof, from the indication determining venous collapse and a transmural pressure at which the venous collapse occurs, and determining the central venous pressure from the transmural pressure at which the venous collapse occurs and from a vertical separation between the individual's heart and the measurement region.
The independent claims focus on applying varying transmural pressures to limb veins, determining pressure-dependent venous volume or blood volume behavior, identifying venous collapse and its transmural pressure, and determining central venous pressure using height or vertical separation information.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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