System and method for incorporating exercise into closed-loop diabetes therapy
Inventors
Ulrich, Thomas R. • Michaud, Michael • Kruse, Geoffrey A. • Harris, Paul • Marin, Garrett
Assignees
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Publication Number
US-12138425-B2
Publication Date
2024-11-12
Expiration Date
Abstract
Disclosed herein are apparatuses and methods that account for exercise in closed loop insulin delivery systems. Rather than increasing a target insulin on board (IOB) as glucose levels rise, which would increase insulin delivery to address the raised glucose levels, when a user indicates that the user will be exercising raised glucose levels are addressed by reducing the target IOB within the closed loop algorithm. By reducing the target IOB, the algorithm responds less aggressively to pre-exercise food, and does not build up the IOB that can cause dangerously low glucose levels once the exercise also begins lowering glucose levels.
Core Innovation
The invention is a system and method for closed loop diabetes therapy that delivers insulin to a user using a closed loop insulin delivery algorithm. The algorithm includes an outer glucose loop that compares glucose levels from a continuous glucose monitor to a glucose target to determine an insulin on board target for the user, and an inner insulin on board loop that compares an estimated insulin on board for the user to the insulin on board target to determine an insulin on board error used to calculate insulin doses.
The system receives an indication that the user will be exercising and activates an exercise mode for the closed loop insulin delivery algorithm in response to the indication. The exercise mode modifies the inner insulin on board loop that calculates the insulin doses, and insulin doses are calculated and delivered to the user based on glucose levels from the continuous glucose monitor according to the exercise mode following the indication.
In described embodiments, the exercise mode modifies how insulin-on-board is managed within the inner insulin on board loop. The modification includes applying a reduced insulin on board target via a temporary constant, increasing an insulin action time used to estimate insulin on board for determining insulin on board error, and/or introducing a temporary basal rate constant that lowers stored basal used for insulin on board estimation without prematurely accelerating insulin on board burn-down.
Claims Coverage
The document includes two independent claims, a system claim and a method claim. Both independent claims share the same core architecture of an outer glucose loop and an inner insulin on board loop, and both require receiving an exercise indication and activating an exercise mode that modifies the inner insulin on board loop for subsequent insulin dosing.
Closed-loop insulin delivery with outer glucose loop and inner insulin on board loop
A closed loop insulin delivery algorithm including an outer glucose loop that compares glucose levels from a continuous glucose monitor to a glucose target to determine an insulin on board target and an inner insulin on board loop that compares an estimated insulin on board to the insulin on board target to determine an insulin on board error used to calculate insulin doses configured to maintain an insulin on board of the user at the insulin on board target and the glucose levels of the user at the glucose target.
Exercise indication-driven activation of exercise mode modifying the inner insulin on board loop
Receiving an indication that the user will be exercising and activating an exercise mode for the closed loop insulin delivery algorithm in response to the indication, the exercise mode modifying the inner insulin on board loop that calculates the insulin doses to maintain the insulin on board of the user at the insulin on board target.
Insulin dosing according to the exercise mode after the exercise indication
Calculating and delivering the insulin doses to the user based on the glucose levels from the continuous glucose monitor according to the exercise mode of the closed loop insulin delivery algorithm following the indication that the user will be exercising.
Method receiving CGM glucose, calculating doses with outer glucose loop and inner insulin on board loop
Receiving glucose levels of a user from a continuous glucose monitor; calculating insulin doses for the user based on a closed loop insulin delivery algorithm including an outer glucose loop that compares the glucose levels from the continuous glucose monitor to a glucose level target to determine an insulin on board target and an inner insulin on board loop that compares an estimated insulin on board to the insulin on board target to determine an insulin on board error used to calculate the insulin doses configured to maintain the estimated insulin on board of the user at the insulin on board target and the glucose levels of the user at the glucose level target.
Method activating exercise mode that modifies the inner insulin on board loop
Receiving an indication that the user will be exercising and activating an exercise mode for the closed loop insulin delivery algorithm in response to the indication, the exercise mode modifying the inner insulin on board loop of the closed loop insulin delivery algorithm that calculates the insulin doses to maintain the estimated insulin on board of the user at the insulin on board target.
Method calculating and delivering insulin doses based on CGM according to exercise mode
Calculating and delivering the insulin doses to the user based on the glucose levels from the continuous glucose monitor according to the exercise mode of the closed loop insulin delivery algorithm following the indication that the user will be exercising.
Overall claim coverage centers on closed-loop insulin delivery using an outer glucose loop to set an insulin on board target and an inner insulin on board loop to compute insulin-on-board error for insulin dosing, together with an exercise indication that activates an exercise mode modifying the inner insulin on board loop for dosing after the indication.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Closed-loop diabetes therapy in which an exercise indication activates an exercise mode for insulin dosing.
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