Mini point of care gas chromatographic test strip and method to measure analytes
Inventors
Morgan, Thomas T. • Carnahan, David L. • NOLAN, Bryan
Assignees
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Publication Number
US-12117429-B2
Publication Date
2024-10-15
Expiration Date
Abstract
A mini point of care gas chromatographic test strip and method to measure analytes is disclosed. A system for determining the concentration of at least one analyte in a fluid sample having a plurality of analytes includes a base substrate, a first electrode pair disposed over the base substrate, and a first sensing chemistry responsive to at least one analyte in the sample. The first sensing chemistry is in electrical communication with the first electrode pair, and a first chromatographic layer is disposed over the at least one sensing chemistry. At least one analyte of the plurality of analytes moves through the first chromatographic layer at a different rate relative to the movement of other analytes of the plurality of analytes.
Core Innovation
The invention relates to a flexible test strip for determining the concentration of at least one analyte in a fluid sample having a plurality of analytes. The system includes a flexible base substrate, an electrode pair disposed over the base substrate, and at least one sensing chemistry responsive to at least one analyte. The sensing chemistry is in electrical communication with the electrode pair, so that electrical measurement of the sensing chemistry is enabled.
A first chromatographic layer is disposed over the at least one sensing chemistry, where the analytes move through the first chromatographic layer at a different rate relative to the movement of other analytes of the plurality of analytes. The first chromatographic layer is affixed to the flexible base substrate and comprises at least one of silicone, sulfonic acid, proton permeable membrane, or acrylic acid. This chromatographic layer provides time-separation based on differential movement rates of different analytes.
The system further includes at least one spacing layer disposed upon at least a portion of the base substrate and upon at least a portion of the electrode pair. The spacing layer at least in part defines a chamber, and the sensing chemistry is disposed within the chamber. The chromatographic layer and chamber arrangement together position the sensing chemistry for measurement while enabling separation of multiple analytes prior to their interaction with the sensing chemistry.
Claims Coverage
Two independent claims are present: a test-strip claim and a method claim. The claims share three inventive features, with the method claim further specifying electrical measurement across the electrode pair.
Flexible base substrate with electrode pair and analyte-responsive sensing chemistry
A flexible base substrate; an electrode pair disposed over the base substrate; at least one sensing chemistry responsive to at least one analyte in the sample, wherein the at least one sensing chemistry is in electrical communication with the electrode pair.
Chromatographic layer producing differential analyte movement rates
A first chromatographic layer disposed over the at least one sensing chemistry, wherein the at least one analyte of a plurality of analytes moves through the first chromatographic layer at a different rate relative to the movement of other analytes of the plurality of analytes; wherein the first chromatographic layer is affixed to the flexible base substrate; and wherein the first chromatographic layer comprises at least one of silicone, sulfonic acid, proton permeable membrane or acrylic acid.
Chamber defined by spacing layers with sensing chemistry disposed within
At least one spacing layer disposed upon at least a portion of the base substrate, and the at least one spacing layer disposed upon at least a portion of the electrode pair, and wherein the at least one spacing layer at least in part defines a chamber, the at least one sensing chemistry disposed within the chamber.
Measuring electrical properties across the electrode pair
Measuring at least one of a voltage across the electrode pair, a resistance across the electrode pair, and a current flow across the electrode pair.
The claims center on a flexible substrate with an electrode pair and sensing chemistry, a first chromatographic layer that separates analytes by different movement rates, and a chamber defined by spacing layers, with the method claim also reciting electrical measurement across the electrode pair.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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