Multi-target treatment planning and delivery and virtual localization for radiation therapy

Inventors

VORONENKO, Yevgen • Pal, Debashish • Larkin, David Quentin • Zdasiuk, George • JANARDHANAN, Jayakrishnan • OWENS, Michael Kirk • OLCOTT, Peter Demetri

Assignees

RefleXion Medical Inc

Abstract

Disclosed herein are methods for patient setup and patient target region localization for the irradiation of multiple patient target regions in a single treatment session. Virtual localization is a method that can be used to register a patient target region without requiring that the patient is physically moved using the patient platform. Instead, the planned fluence is updated to reflect the current location of the patient target region by selecting a localization reference in the localization image, calculating a localization function based on the localization reference point, and calculating the delivery fluence by convolving the localization function with a shift-invariant firing filter. Mosaic multi-target localization partitions a planned fluence map for multiple patient target regions into sub-regions that can be individually localized. De-coupled multi-target localization involves generating a separate planned fluence map for each target but constraining a cumulative fluence map to ensure dosimetric goals are met.

Core Innovation

The invention provides a method for virtual target region localization and radiation delivery by acquiring an image of a patient in a treatment position and identifying a patient target region in the acquired image. A localization reference point is selected within the acquired image and corresponds with a planned localization reference point, and a localization function is calculated based on the localization reference point.

The calculated localization function is applied to a shift-invariant firing filter derived based on the planned localization reference point to calculate a fluence for delivery to the patient target region at each firing position of a therapeutic radiation source. The computed delivery fluence is then emitted using the therapeutic radiation source to the patient target region.

In related aspects, a spatial offset is calculated based on the shift between the localization reference point and the planned localization reference point. A boundary of a planned region of interest is shifted based on the spatial offset such that the boundary surrounds the patient target region, and imaging data that has been spatially filtered by the shifted region of interest is acquired.

Claims Coverage

The provided independent claims are clm-00001 and clm-00041. Across these claims, the inventive coverage centers on selecting a localization reference point corresponding with a planned localization reference point, calculating delivery fluence at each firing position using a localization function applied to a shift-invariant firing filter derived from the planned localization reference point, and emitting the resulting delivery fluence to a patient target region; clm-00041 further adds spatial-offset region-of-interest shifting and spatially filtered imaging data acquisition.

Claim coverage is focused on virtual target region localization that drives radiation delivery fluence computation using a localization function tied to a selected localization reference point and a shift-invariant firing filter derived from a planned localization reference point, with radiation emitted using the computed delivery fluence. Claim clm-00041 additionally localizes by calculating a spatial offset and shifting a planned region-of-interest boundary to surround the patient target region, and then acquiring spatially filtered imaging data before computing and emitting delivery fluence.

Stated Advantages

Documented Applications

No documented applications found