Method for prevention and reduction of skin stasis with compositions and materials comprising copper compounds
Inventors
LUSTIGER, Danny • Borkow, Gadi
Assignees
Publication Number
US-12097216-B2
Publication Date
2024-09-24
Expiration Date
2039-10-28
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Abstract
The present application relates to a method for reduction and prevention of damaged skin stasis comprising applying a material containing water-soluble or water-insoluble copper compounds to said damaged skin.
Core Innovation
The invention provides a method for reduction and prevention of damaged skin stasis by applying a material containing water-soluble or water-insoluble copper compounds to the damaged skin. The copper compounds may be incorporated into various materials such as woven or non-woven fabrics, foams, knitted fabrics, polymeric films, fibers, filaments, or sheaths used in wound dressings, plasters, and gauze. These materials are impregnated or coated with copper compounds, including cuprous iodide (CuI), cuprous oxide (Cu2O), or cupric oxide (CuO), in amounts typically ranging from about 0.1-10% weight/weight.
The problem addressed by this invention stems from the harmful effects of skin burns, particularly the progression and expansion of wound injury within the zone of stasis—a region surrounding the zone of coagulation where tissue perfusion is decreased and where cells may either survive or die depending on the severity of the burn. This zone represents a critical therapeutic target since its damage contributes significantly to wound size increase after burn injuries. Existing challenges include managing the inflammatory responses, infection, and tissue damage that exacerbate burn wounds and lead to complicated healing processes and systemic responses.
The innovation lies in the discovery that applying copper compounds locally to burnt skin can reduce the progression of damage within the zone of stasis by modulating inflammatory cytokines and promoting tissue regeneration. The materials containing copper compounds release copper ions upon contact with damaged skin, which has been demonstrated to reduce pro-inflammatory cytokines (IL-6, IL-8, TGF-β), inhibit wound size increase, promote keratinocyte proliferation and re-epithelialization, and enhance collagen and elastin production, thereby improving healing outcomes.
Claims Coverage
The patent includes one independent claim that outlines the main method and its essential features involving materials impregnated or coated with copper compounds for treating burnt skin.
Method for preventing formation of a zone of stasis using copper-impregnated materials
A method comprising applying a material impregnated or coated with about 0.1-10% weight/weight water-insoluble copper particles to a burnt skin area immediately after the skin burn before inflammatory response occurs.
Use of diverse material types for copper application
The material is selected from woven or non-woven fabrics, foams, knit fabrics, polymeric films, fibers, filaments, or sheaths used in manufacturing medical items.
Specific copper compound particles in materials
The water-insoluble copper particles are chosen from cuprous iodide (CuI), cuprous oxide (Cu2O), cupric oxide (CuO), or combinations thereof.
The claim sets focus on a method for reducing and preventing skin stasis by applying various types of copper particle-containing materials immediately after burn injury, specifying material forms and copper compound types that achieve this effect.
Stated Advantages
Reduction of the burn wound size progression, particularly in the zone of stasis, thus preventing enlargement of the wound.
Suppression of pro-inflammatory cytokines (IL-6, IL-8, TGF-β) associated with burn-induced inflammation.
Promotion of keratinocyte proliferation and re-epithelialization, enhancing the wound healing process.
Increased production and deposition of collagen and elastin fibers in dermal layers, supporting tissue remodeling and stability.
Documented Applications
Use of copper compound-containing materials such as wound dressings, plasters, gauze, foams, or polymeric films for treatment of thermal skin burns to reduce and prevent damage in the zone of stasis.
Topical application of copper ion-containing compositions or materials immediately following burn injury to modulate inflammation and promote healing.
Use of copper-impregnated woven or non-woven fabrics and polymeric materials for wound care and skin regeneration in thermal burns.
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