Drug delivery device with electrically controlled volume changing means
Inventors
Goldstein, Jonathan • Fleischer, Niles • Rotem, Nir • Bar-Gat, Lior • Piskosh, Vladimir
Assignees
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Publication Number
US-12097028-B2
Publication Date
2024-09-24
Expiration Date
Abstract
A displacement-generating battery cell for driving a drug-delivery device is described. The cell may include at least one volume-changing element. The cell may include a housing formed according to a concertina-shaped design with folds in the walls thereof and may contain an internal chemical reaction system. The chemical reaction system may include an electrode. The electrode may be the volume-changing element. The arrangement of said chemical reaction system may be such that an expansion of the volume-changing element in a direction lengthens the cell and thus reduces the extent of the folds. Drug-delivery devices including the displacement-generating battery cell are also described.
Core Innovation
The invention relates to a self-powered drug-delivery device driven by an electrically-controlled, non-gas-evolving displacement-generating electrochemical battery cell. The battery cell includes at least one volume-changing element, where an electrode is the volume-changing element within an internal chemical reaction system. The cell is arranged so that expansion of the volume-changing element in a direction lengthens the cell and reduces the extent of folds in a concertina-shaped housing with folds in walls thereof.
Expansion of the volume-changing element is mechanically conveyed to displace a wall of a drug reservoir chamber, so that the expansion results in displacement of the drug reservoir wall for delivery. The arrangement couples the displacement-generating battery cell and the drug reservoir chamber such that drug expulsion is driven by the battery-cell expansion behavior rather than by gas generation. The housing and chemical reaction system configuration are used to produce controlled displacement for driving the drug-delivery device.
The disclosure further specifies structural and functional refinements for the displacement-generating battery cell, including a mesh surrounding the electrode and directional behavior such as lengthening of the cell with reduced fold extent. The electrode can be arranged on a printed circuit board, and at least one component of the displacement-generating battery cell can undergo a volume change of at least 30%. The chemical reaction system can be chosen from a group including Li-Sn, (Li)LiC6-Sn, Fe-LaNi5, lithium-lead, lithium-antimony, lithium-silicon, and lithium bismuth, and can be non-gassing.
Claims Coverage
The independent claims identified are clm-00001, clm-00019, clm-00020, clm-00021, clm-00022, clm-00023, clm-00024, clm-00025, clm-00026, and clm-00027. Across these claims, the coverage centers on a concertina-shaped, fold-walled displacement-generating battery cell with a volume-changing element that is an electrode, arranged so that expansion lengthens the cell and reduces fold extent, including coupling to a drug reservoir chamber for wall displacement.
Concertina-shaped displacement-generating battery cell with electrode volume-changing element
A displacement-generating battery cell for driving a drug-delivery device comprising at least one volume-changing element, where the cell comprises a housing formed according to a concertina-shaped design with folds in walls thereof and containing an internal chemical reaction system; the chemical reaction system comprises an electrode, and the electrode is the volume-changing element; the arrangement is such that an expansion of the volume-changing element in a direction lengthens the cell and thus reduces the extent of said folds.
Mesh surrounding the electrode
The displacement-generating battery cell further comprises a mesh surrounding the electrode.
Drug-delivery device coupled to reservoir wall displacement
A drug-delivery device comprising a drug reservoir chamber containing a substance to be delivered and a displacement-generating battery cell, wherein the cell expansion is such that expansion of the volume-changing element results in a displacement of a wall of the drug reservoir chamber.
Electrode on a printed circuit board
A displacement-generating battery cell in which the electrode is on a printed circuit board.
At least 30% volume change in a component
A displacement-generating battery cell wherein at least one component of the displacement-generating battery cell undergoes a volume change of at least 30%.
Chemical reaction system selected from a group of lithium-based systems
A displacement-generating battery cell wherein the chemical reaction system is chosen from the group consisting of Li-Sn, (Li)LiC6-Sn, Fe-LaNi5, lithium-lead, lithium-antimony, lithium-silicon, and lithium bismuth.
Tin electrode
A displacement-generating battery cell wherein the electrode comprises tin.
First electrode and second electrode including lithium
A displacement-generating battery cell wherein the electrode is a first electrode, and the displacement-generating battery cell further comprises a second electrode, the second electrode comprising lithium.
Organic solvent or polymer electrolyte with lithium ion-providing salt
A displacement-generating battery cell comprising at least one volume-changing element and an organic solvent or a polymer electrolyte together with a lithium ion-providing salt.
Electrolyte with EC/EMC solvent mixture and LiPF6
A displacement-generating battery cell comprising at least one volume-changing element and an electrolyte comprising a solvent of a mixture of ethylene carbonate and ethyl methyl carbonate with dissolved lithium hexafluorophosphate.
Non-gassing chemical reaction system
A displacement-generating battery cell wherein the chemical reaction is non-gassing.
The independent claim set broadly covers a displacement-generating electrochemical battery cell with a concertina-shaped, folded-wall housing and an internal chemical reaction system in which an electrode acts as a volume-changing element that expands to lengthen the cell and reduce fold extent. Coverage is extended to a drug-delivery device by coupling battery-cell expansion to displacement of a reservoir wall, and is further refined through limitations such as mesh surrounding the electrode, electrode on a printed circuit board, at least a 30% volume change in a component, specified chemical reaction system choices, specified electrode materials, specified second electrode lithium, specified electrolyte/solvent selections, and a non-gassing chemical reaction.
Stated Advantages
Provides a self-powered drug-delivery device driven by an electrically-controlled, non-gas-evolving displacement-generating electrochemical battery cell.
Avoids gas-generation dependence compared with gas-driven infusion systems.
Enables precise dosing via controlled electrochemical discharge and expansion behavior.
Supports waterproofing and minimal moving parts through device configurations with fewer moving parts.
Allows displacement driven by controlled battery-cell expansion lengthening and reduction of fold extent.
Documented Applications
Driving a drug-delivery device using a displacement-generating battery cell coupled to a drug reservoir chamber.
Using the displacement-generating battery cell in drug-delivery device configurations including a drug reservoir chamber with an administered substance for delivery through drug administration means.
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