System and method for outcome tracking and analysis

Inventors

Pellini, Michael • Palmer, Gary • Lancelotta, Mary Patricia • Hawryluk, Matthew J. • Miller, Vincent A.

Assignees

Foundation Medicine Inc

Abstract

Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.

Core Innovation

The invention relates to tracking cancer treatment and outcome information using a model that analyzes treatment data and outcome data. The model indexes outcome data based on one or more genomic-based indices and specifies a data structure that includes the one or more genomic-based indices. Treatment and outcome information are received as user input indicative of an update to a patient’s treatment or outcome via a first user interface with user interface controls that categorize treatment information and outcome information into selectable categories to minimize time required by a physician to input data.

The model processes the user input and dynamically identifies a set of patients similar to the patient based on the model. After receiving an instruction for viewing similar patients, a second user interface is configured based at least partially on the model by generating a treatment data structure associated with the set of patients similar to the patient. The treatment data structure provides actionable information or advisory information for treatment decision making, including enabling a physician to locate treatment information and outcome information for dynamically identified similar patients.

The disclosure further centers on organizing and analyzing records by genomic alteration, affected gene/pathway, tumor type, and treatment, and dynamically identifies similar patient populations for filterable similar patient and patient-group outcome views. Outcome statuses are normalized among complete response, partial response, stable disease, and progressive disease, and course-of-treatment timelines are displayed to support review of treatment and outcomes over time.

Claims Coverage

The document includes three independent claims: a method, an electronic device, and a non-transitory computer-readable storage medium. Across these independent claims, the core inventive elements are generating a genomic-indexed model for treatment and outcome analysis, receiving categorized physician updates via a first user interface, dynamically identifying similar patients, and configuring a second user interface to display actionable or advisory treatment and outcome information for off-label treatment decision making.

Taken together, the independent claims cover a workflow in which a model indexes and analyzes treatment and outcome data using genomic-based indices, physician updates are entered through a categorized interface, similar patients are dynamically identified, and a second interface presents treatment and outcome information as actionable or advisory content to inform off-label treatment decision making.

Stated Advantages

Documented Applications