Blood purification apparatus
Inventors
Furuhashi, Tomohiro • Eda, Yuki • Ohta, Masaaki • Ono, Kazuhide
Assignees
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Publication Number
US-12083257-B2
Publication Date
2024-09-10
Expiration Date
Abstract
A blood purification apparatus capable of performing pre-substitution and post-substitution simultaneously is provided. A patient's blood flows through an arterial blood circuit and reaches a dialyzer. The blood purified by the dialyzer flows through a venous blood circuit and returns into the patient. A first substitution pump delivers substitution fluid through a substitution line to a branching point. A pre-substitution line connects the branching point and the arterial blood circuit to each other and is provided with a second substitution pump at a halfway position thereof. A post-substitution line connects the branching point and the venous blood circuit to each other and is provided with a check valve at a halfway position thereof. When the two pumps are activated simultaneously, the substitution fluid is supplied to the arterial blood circuit (pre-substitution). When only the first substitution pump is activated, the substitution fluid is supplied to the venous blood circuit (post-substitution). When the flow rate of the second substitution pump is set higher than the flow rate of the first substitution pump, pre-substitution and post-substitution are performed simultaneously.
Core Innovation
The invention relates to a blood purification apparatus in which a patient's blood extracorporeally circulates through an arterial blood circuit and a venous blood circuit, with a blood purifier interposed between the arterial blood circuit and the venous blood circuit. Substitution fluid is introduced by a pre-substitution line into the arterial blood circuit for pre-substitution and by a post-substitution line into the venous blood circuit for post-substitution, and a substitution line connects a substitution-fluid source to the pre-substitution line and the post-substitution line.
The apparatus includes substitution pumps controlled by a control unit, and each substitution pump is a peristaltic pump that delivers liquid by squeezing a flexible tube. A first substitution pump is provided to the substitution line, and a second substitution pump is provided to one of the pre-substitution line and the post-substitution line. A heating bag to be heated by a heating device is attached to a position of the substitution line between the first substitution pump and a branching part of the pre-substitution line and the post-substitution line.
An air trap chamber is provided at a position between the heating device and the arterial blood circuit or the venous blood circuit to trap bubbles in the substitution fluid. A check valve is provided to one of the pre-substitution line and the post-substitution line. A pressure sensor detects a fluid pressure in a portion between the first substitution pump and the second substitution pump in the substitution line and in the pre-substitution line and the post-substitution line, and the control unit corrects a driving speed of the first substitution pump or the second substitution pump in accordance with the detected fluid pressure to remove a negative pressure or a positive pressure and prevent backflow.
Claims Coverage
The independent claim defines one integrated blood purification apparatus concept with six inventive features, and the dependent claims further refine pump allocation, simultaneous pre-/post-substitution, and check-valve placement.
Pre- and post-substitution with shared substitution line
A blood circuit with an arterial blood circuit and a venous blood circuit, a blood purifier interposed between the arterial blood circuit and the venous blood circuit, a pre-substitution line for introducing substitution fluid into the arterial blood circuit, a post-substitution line for introducing substitution fluid into the venous blood circuit, and a substitution line connecting a substitution-fluid source to the pre-substitution line and the post-substitution line.
Peristaltic substitution pumps with first and second pumps on selected lines
Substitution pumps controlled by a control unit, each substitution pump being a peristaltic pump, including a first substitution pump provided to the substitution line and a second substitution pump provided to one of the pre-substitution line and the post-substitution line.
Heating bag on the substitution line between first substitution pump and branching part
A heating bag to be heated by a heating device and attached to a position of the substitution line between the first substitution pump and a branching part of the pre-substitution line and the post-substitution line.
Air trap chamber positioned between heating device and arterial/venous circuit
An air trap chamber provided at a position between the heating device and the arterial blood circuit or the venous blood circuit to trap bubbles in the substitution fluid.
Pressure sensor and driving-speed correction to remove negative/positive pressure
A pressure sensor that detects a fluid pressure in a portion between the first substitution pump and the second substitution pump in the substitution line and in the pre-substitution line and the post-substitution line, and a control unit that corrects a driving speed of the first substitution pump or the second substitution pump in accordance with the detected fluid pressure to remove a negative pressure or a positive pressure generated in the flow route for the substitution fluid.
Check valve placement in one of the pre-substitution or post-substitution lines
A check valve provided to one of the pre-substitution line and the post-substitution line.
The claims center on a pre- and post-substitution substitution-fluid delivery system for extracorporeal blood purification using peristaltic substitution pumps, with a heating bag between the first pump and the branching part, an air trap chamber downstream of the heating device, pressure-sensor-based driving-speed correction to remove negative or positive pressure, and check-valve placement in one of the substitution lines.
Stated Advantages
Allows substitution-fluid consumption by removing a negative pressure or a positive pressure generated in the flow route for the substitution fluid.
Prevents backflow via the check valve.
Reduces negative-pressure impact and heating-bag cost by attaching a single heating bag to a position of the substitution line between the first substitution pump and the branching part.
Documented Applications
Use in a blood purification apparatus that extracorporeally circulates a patient's blood through a blood purifier with substitution fluid introduced for pre-substitution and post-substitution through arterial and venous circuits.
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