Delivery of hydrophobic active agent particles
Inventors
Slager, Joram • Heyer, Toni M. • Babcock, David E.
Assignees
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Publication Number
US-12083249-B2
Publication Date
2024-09-10
Expiration Date
Abstract
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
Core Innovation
The invention provides a drug delivery coating that includes a base polymeric layer with a hydrophilic surface and a therapeutic agent layer forming an exterior surface of the coating. The therapeutic agent layer contacts the hydrophilic surface and has a composition different from the base polymeric layer. The therapeutic agent layer includes a hydrophobic therapeutic agent comprising rapamycin or a rapamycin analogue and a cationic agent.
A key constraint of the coating composition is that a ratio (wt./wt.) of particulate hydrophobic therapeutic agent to the cationic agent is about 99.9/0.1 to 90/10. This defines how the rapamycin or rapamycin analogue particulate hydrophobic therapeutic agent is combined with the cationic agent within the therapeutic agent layer.
In the described refinements, the base polymeric layer includes a hydrophilic polymer having pendent photoreactive groups, and at least one photo-polyacrylamide component is specified by particular polyacrylamide-based copolymers. Further refinements define selection of the photo-polyacrylamide and specify a photo crosslinker identity, thereby integrating photo-reactive functionality with the hydrophilic base layer and the therapeutic agent layer.
Claims Coverage
The consolidated claim coverage includes one independent claim. The main inventive coverage is defined by a hydrophilic base polymeric layer and an exterior therapeutic agent layer containing particulate hydrophobic rapamycin or a rapamycin analogue plus a cationic agent, constrained by a wt./wt. ratio of hydrophobic therapeutic agent to cationic agent; dependent claim refinements add photoreactive hydrophilic base-layer chemistry and specify particular photo-polyacrylamide and photo crosslinker selections.
Hydrophilic base polymeric layer with exterior therapeutic agent layer
A drug delivery coating comprising a base polymeric layer with a hydrophilic surface and a therapeutic agent layer forming an exterior surface that contacts the hydrophilic surface and has a composition different from the base polymeric layer.
Rapamycin or rapamycin analogue with cationic agent
The therapeutic agent layer comprising a hydrophobic therapeutic agent comprising rapamycin or a rapamycin analogue and a cationic agent.
Particulate wt./wt. ratio of hydrophobic therapeutic agent to cationic agent
A ratio (wt./wt.) of particulate hydrophobic therapeutic agent to the cationic agent is about 99.9/0.1 to 90/10.
Hydrophilic polymer with pendent photoreactive groups in the base layer
The base polymeric layer includes a hydrophilic polymer with pendent photoreactive groups.
Selected photo-polyacrylamide components
The photo-polyacrylamide component is selected from specific named polyacrylamide-based copolymers.
Specific photo-polyacrylamide and photo crosslinker combination
The photo-polyacrylamide is poly(N-3-aminopropyl)methacrylamide-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide and the photo crosslinker is ethylenebis(4-benzoylbenzyldimethylammonium) dibromide.
Across the independent claim and its dependent refinements, the coverage centers on a coating architecture that couples a hydrophilic base polymeric layer to an exterior therapeutic agent layer containing particulate rapamycin or a rapamycin analogue and a cationic agent under a defined wt./wt. ratio constraint, with additional claim scope provided by photoreactive hydrophilic base-layer features and specified photo-polyacrylamide/photo crosslinker selections.
Stated Advantages
Documented Applications
No documented applications found
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