Device for the capture and removal of disease material from fluids
Inventors
MILLER, Sinead E. • Ransden, Jeffrey • Bachman, Alan
Assignees
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Publication Number
US-12078630-B2
Publication Date
2024-09-03
Expiration Date
Abstract
A device for the capture and adsorption of blood-borne materials of interest comprising a fluidic cartridge with at least one inlet and at least one outlet; a multidirectional fluidic channel between the at least one inlet and the at least one outlet; said multidirectional fluidic channel comprising at least one inner wall; and a substance coating at least a portion of the at least one inner wall of the multidirectional fluidic channel.
Core Innovation
The invention describes an extracorporeal fluidic cartridge for capturing and adsorbing blood-borne materials of interest. The cartridge includes at least one inlet and at least one outlet and a multidirectional fluidic channel formed by two or more stackable filter plates arranged in a stackable plate configuration. Each filter plate has at least one plate inlet, at least one plate outlet, and a fluidic channel with a curved shape, such that the multidirectional fluidic channel is fluidically connected with the inlet and outlet of the cartridge.
The multidirectional fluidic channel includes at least one inner wall, and the inner wall is provided with a first substance coating at least a portion of the inner wall. The first substance is effective to capture or to adsorb blood-borne materials, and the curvature of the multidirectional fluidic channel is configured to promote capture or adsorption of the blood-borne materials by the coating when the blood-borne materials of interest are flowed through the multidirectional fluidic channel.
The disclosed first substance coating is described as primarily a fixed/covalently-bonded capture substance, including polypeptide antibiotics such as polymyxin and polymyxin E (colistin) and/or vancomycin, with broad options for coating agents including antibodies, peptides, proteins, polymers, aptamers, and crosslinkers. The document further describes sample fluid treatment and diagnostic concepts based on capturing or adsorbing pathogens/toxins and detecting captured materials using cell counting, MALDI-TOF MS, PCR, or related detection approaches.
Claims Coverage
The provided independent claim is directed to a blood-borne materials capture and adsorption device that includes a stacked multi-plate multidirectional curved fluidic channel cartridge and an inner-wall coating whose capture/adsorption is promoted by channel curvature. The claim set centers on 3 inventive features, with dependent claims refining aspects of channel geometry, stack configuration, inlet/outlet connectivity, and coating/capture specifications.
Multidirectional curved fluidic channel in stacked filter plates
A fluidic cartridge with at least one inlet and at least one outlet; two or more filter plates arranged in a stackable plate configuration to collectively form a multidirectional fluidic channel having at least one inner wall, wherein the fluidic channel comprises a curved shape fluidically connected with plate inlets and plate outlets and the multidirectional fluidic channel is fluidically connected with the inlet and the outlet of the fluidic cartridge.
Inner-wall capture or adsorption substance coating
A first substance coating at least a portion of the at least one inner wall of the multidirectional fluidic channel, wherein the first substance is effective to capture or to adsorb blood-borne materials.
Curvature configured to promote capture or adsorption during flow
A curvature of the multidirectional fluidic channel configured to promote the capture or the adsorption of the blood-borne materials by the first substance coating the inner wall when the blood-borne materials of interest is flowed through the multidirectional fluidic channel.
Overall, the claim set centers on a cartridge with a stacked multi-plate multidirectional curved channel whose inner wall carries a capture/adsorption coating, with the channel curvature configured to enhance capture/adsorption during flow.
Stated Advantages
Promotes capture or adsorption of blood-borne materials by the first substance coating the inner wall when blood-borne materials flow through the multidirectional fluidic channel.
Curved flow concentrates particulates near coated walls.
Documented Applications
Capture and adsorption of blood-borne pathogens/toxins associated with sepsis-related conditions, including bacteremia/endotoxemia contexts described in the document.
Diagnostic use where captured materials are detected using cell counting, MALDI-TOF MS, PCR, or other described detection concepts after capture/adsorption.
Endotoxin capture from blood-borne materials, with documented comparisons versus PEGylated controls.
Capture of antibiotic-resistant organisms and Gram-positive and Gram-negative bacteria using polypeptide antibiotic coatings described in the document.
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