Systems and methods for cooperative invasive and noninvasive brain stimulation
Inventors
Assignees
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Publication Number
US-12076570-B2
Publication Date
2024-09-03
Expiration Date
Abstract
Methods and systems for optimizing invasive and noninvasive brain stimulation are described herein. In a particular embodiment, methods and systems for a combinatorial, iterative approach to modify behavior are presented wherein deep brain stimulation (DBS) and other brain stimulation therapies are implemented in combination with monitoring the brain activity of an individual to optimize the effectiveness of the combinatorial approach to modify behavior. Methods described herein are iterative and systems described herein are utilized in iterative fashion. In a particular embodiment, modifying behavior provides a therapy for an individual in need thereof.
Core Innovation
A system administers at least one stimulus to modulate an individual’s brain electrical activity while the individual is performing a particular activity. The system detects both the particular activity and the brain electrical activity associated with the particular activity while the individual is performing the particular activity, and the stimulus is configured to promote the ability of the individual to perform the particular activity.
A specifically programmed computer system coupled to the stimulation device and the apparatus projects, in real time, the detected brain electrical activity onto a denoised optimal set of wavelet packet atoms to obtain a particular set of projections. The computer system assesses, in real time, the brain electrical activity relative to a representative brain electrical activity of a plurality of individuals performing the particular activity by applying at least one machine learning algorithm to the particular set of projections.
The at least one machine learning algorithm is trained by the plurality of individuals performing the particular activity and the brain electrical activity collected from the plurality of individuals associated with performing the particular activity. The computer system determines a relationship between the particular activity, the detected brain electrical activity, the real-time assessment relative to the representative brain electrical activity, and the at least one stimulus, and based on the relationship causes adjusting the at least one stimulus from the stimulation device to promote the ability of the individual to perform the particular activity.
Claims Coverage
The partial content provides three independent claims: clm-00001, clm-00006, and clm-00016. Across these claims, there are three core inventive feature groups: real-time stimulation of brain electrical activity during a particular activity to promote ability, real-time denoised wavelet packet atom projection of detected brain electrical activity, and machine-learning-based real-time assessment relative to representative brain electrical activity of a plurality of individuals followed by relationship-based adjustment of the stimulus.
Real-time projecting of detected brain electrical activity onto denoised optimal wavelet packet atoms
Projecting, in real time, the detected brain electrical activity of the individual while the individual is performing the particular activity onto a denoised optimal set of wavelet packet atoms to obtain a particular set of projections of the individual.
Machine-learning-based real-time assessment versus representative activity-associated brain electrical activity
Assessing, in real time, the brain electrical activity of the individual while the individual is performing the particular activity relative to a representative brain electrical activity of a plurality of individuals performing the particular activity by applying at least one machine learning algorithm to the particular set of projections of the individual, wherein the at least one machine learning algorithm is trained by the plurality of individuals performing the particular activity and the brain electrical activity collected from the plurality of individuals associated with performing the particular activity.
Relationship-based adjusting of the stimulus to promote ability
Determining a relationship between the particular activity performed by the individual, the detected brain electrical activity of the individual associated with the particular activity, the assessing, in real time, of the brain electrical activity of the individual associated with the particular activity relative to the representative brain electrical activity of the plurality of individuals performing the particular activity by using the at least one machine learning algorithm, and the at least one stimulus, and causing to adjust, based on the relationship, the at least one stimulus from the stimulation device to promote the ability of the individual to perform the particular activity.
Real-time adjustive stimulation to modulate brain electrical activity during a particular activity to promote ability
Administering at least one stimulus to modulate brain electrical activity of an individual while the individual is performing the particular activity, wherein the at least one stimulus promotes the ability of the individual to perform the particular activity.
Reducing a symptom of the disease or disorder by relationship-based adjusting
Adjusting, based on the relationship, the at least one stimulus to promote the ability of the individual to perform the particular activity, thereby reducing at least one symptom of the disease or disorder.
Across the independent claims, the coverage centers on real-time processing of detected brain electrical activity using denoised optimal wavelet packet atoms, real-time machine-learning assessment relative to representative brain electrical activity of a plurality of individuals, determination of a relationship including the stimulus, and relationship-based adjusting of the stimulus to promote ability; in clm-00016, the adjustment is tied to reducing at least one symptom of a disease or disorder.
Stated Advantages
Promotes the ability of the individual to perform the particular activity.
In at least one method variant, reduces at least one symptom of the disease or disorder.
Documented Applications
Treating individuals having impaired ability related to performing a particular activity due to a disease or disorder, including Parkinson's disease, tremors, motor dysfunction, dyskinesia, gate freeze, epilepsy, migraine headaches, pain, anxiety, depression, mood swings, attention deficit disorders, sleep disorders, or cognitive decline disorders.
Applicable to particular activities including walking, resuming walking, and an anxiety-provoking activity.
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