Medicament delivery device
Inventors
Cottenden, David • Wang, Jianye • Young, Duncan • Cheung, Desmond • Waddelow, Simon • McDerment, Iain • Selby, Rob • Wyman, Catherine • May, Rob • Groombridge, Chris
Assignees
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Publication Number
US-12076481-B2
Publication Date
2024-09-03
Expiration Date
Abstract
A manifold for a medicament delivery device configured to deliver discrete doses of medicament contained in a plurality of individual compartments spaced along a carrier strip and sealed by a sealing layer to form a medicament carrier, the manifold comprising: at least one opening mechanism comprising a release member arranged to engage between the carrier strip and the sealing layer of a medicament carrier so as to separate the sealing layer from the carrier strip and thereby open a compartment of the medicament carrier as it is advanced into an entrainment position; wherein the release member includes a surface configured to cover the opened compartment when in the entrainment position so as substantially to contain the medicament dose of said opened compartment.
Core Innovation
The invention relates to a manifold for a medicament delivery device that delivers discrete doses of dry powder medicament contained in a plurality of individual compartments spaced along a carrier strip and sealed by a sealing layer to form a medicament carrier. The manifold includes at least one opening mechanism that uses a release member arranged to engage between the carrier strip and the sealing layer, thereby separating the sealing layer from the carrier strip and opening a compartment as it is advanced into an entrainment position. The release member includes a surface configured to cover the opened compartment when in the entrainment position so as substantially to contain the medicament dose of the opened compartment.
The manifold further includes a cylindrical indexing wheel with a plurality of indentations spaced around its exterior surface, where each indentation is configured to receive a compartment of the medicament carrier. Rotation of the indexing wheel advances the medicament carrier and moves the plurality of individual compartments sequentially into the entrainment position. The indexing wheel has an axial through-bore arranged to be in fluid communication with a side of the release-member surface facing the carrier strip, such that the indexing wheel and the release member form part of an entrainment airpath.
In the described configuration, air is routed along or over the release-member surface in the entrainment airpath to entrain the exposed dose in the opened compartment. The description also includes a bypass airpath that directs air to bypass the release member, and the entrainment airpath and bypass airpath merge downstream.
Claims Coverage
The relevant content provides one independent claim with three main inventive feature groups.
Release member separating sealing layer and containing opened compartment at entrainment position
A release member arranged to engage between the carrier strip and the sealing layer of the medicament carrier so as to separate the sealing layer from the carrier strip and thereby open a compartment of the medicament carrier as it is advanced into an entrainment position; the release member includes a surface configured to cover the opened compartment when in the entrainment position so as substantially to contain the medicament dose of said opened compartment.
Cylindrical indexing wheel with indentations for sequential advancement into entrainment position
A cylindrical indexing wheel having a plurality of indentations spaced around its exterior surface, each indentation configured to receive a compartment from the plurality of individual compartments such that rotation of the indexing wheel advances the medicament carrier and thereby moves the plurality of individual compartments sequentially into the entrainment position.
Entrainment airpath formed by indexing wheel axial through-bore and release-member surface side facing carrier strip
The indexing wheel has an axial through-bore arranged to be in fluid communication with a side of said surface of the release member arranged to face the carrier strip such that the indexing wheel and the release member thereby form part of an entrainment airpath.
Across the independent claim, the core coverage is the combination of a release member that separates the sealing layer and covers the opened compartment at the entrainment position to substantially contain the dose, a cylindrical indexing wheel with indentations for sequential compartment movement into the entrainment position, and an entrainment airpath portion formed by the indexing wheel axial through-bore in cooperation with the release-member surface facing the carrier strip.
Stated Advantages
Substantially contains the medicament dose of an opened compartment when the compartment is in the entrainment position.
Documented Applications
Dry powder medicament delivery using a manifold for delivering discrete doses of medicament contained in individual compartments spaced along a carrier strip and sealed by a sealing layer, with an entrainment airpath at an entrainment position.
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