Oral delivery of active drug substances
Inventors
Skak, Nikolaj • Lindhardt, Karsten • Elhauge, Torben • Olsen, Martin Rex
Assignees
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Publication Number
US-12070566-B2
Publication Date
2024-08-27
Expiration Date
Abstract
The present disclosure relates to a delivery device capable of delivering compositions. In some embodiments, the delivery device may deliver compositions to the gastrointestinal tract. In some embodiments, the compositions contain active drug substances. In some embodiments, the active drug substances are low permeable active drug substances.
Core Innovation
The invention relates to an oral delivery device for a composition comprising a delivery device with a body and a delivery part. The body extends along a body axis from a first body end to a second body end and has a body surface, and the delivery part comprises a first attachment part having a first distal end and is configured by a first bend that extends along a first axis, wherein a first angle between the first axis and the body axis is less than 75 degrees.
The delivery device is configured to be positioned in internal tissue of a subject, including positioning of the first distal end in an internal surface. The first attachment part can be arranged with a distance of at least 0.5 mm from the body surface, and the distal end can be positioned between the first body end and the second body end.
The attachment part can comprise a first bevel surface forming a cutting edge, with the bevel including a concave bevel surface and a cutting zone/hooking zone. The device includes a delivery part/material system using thermoplastic polymers that protect and later release a payload, with optional pH-dependent soluble materials and optional water-insoluble/biodegradable materials.
A first cavity can accommodate a payload that includes an active drug substance, including low-permeable active drug substance such as insulin. A separation part can be configured to break upon attachment to internal tissue, thereby separating the body from the first attachment part, leaving the attachment portion in tissue.
Claims Coverage
The document provides three independent claim foundations. Across these independent claims, the main inventive features include a bent or curved attachment part with a sub-75° angle relative to the body axis, placement of a distal end into an internal surface, and payload accommodation in a cavity for an active drug substance.
Bent attachment part with sub-75° angle
A delivery device having a body axis and a first attachment part extending along a first axis such that a first angle between the first axis and the body axis is less than 75 degrees.
Internal surface positioning with bounded attachment length
A delivery device where the first attachment part has a first distal end configured to position itself in an internal surface of a subject, wherein the first attachment part comprises a first bend and has a length in the range from 1.0 mm to 20 mm.
Curved delivery part with internal-surface positioning
A delivery device where the delivery part is curved and comprises a first attachment part having a first distal end configured to position itself in an internal surface of a subject.
Overall, the independent claims are directed to a delivery device whose attachment portion is bent or curved with an angle constraint, configured to place a distal end on an internal surface, and sized to include a bounded attachment length. Payload accommodation in a cavity for an active drug substance is also set out in the independent claim family around internal-surface positioning.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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