Organ perfusion apparatus with downstream flow control
Inventors
Kravitz, David • Steinman, Christopher P. • Louis, Jeffrey S. • Copithorne, Matthew • Otts, Brian • Demuylder, Peter
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12070028-B2
Publication Date
2024-08-27
Expiration Date
Abstract
An apparatus for perfusing an organ or tissue includes a perfusion circuit for perfusing the organ or tissue; a controller configured to control the apparatus; and a detector configured to detect an optional component of the apparatus, and provide a signal to the controller indicative of the presence of the optional component, wherein the controller is configured to control the perfusion circuit in a first mode when the optional component is detected and to control the perfusion circuit in a second mode when the optional component is not detected.
Core Innovation
The invention relates to an organ perfusion apparatus that includes a perfusion circuit and a controller configured to control the apparatus. The apparatus uses multiple tube entry paths to provide a flow balance between tubes, including a portal and hepatic flow paths. Clinician-controlled valves or clamps alter the flow balance without changing the pump fluid motive force.
The apparatus further includes sensors to monitor flow and pressure in real time, including a pressure sensor and a flow sensor, as well as bubble detection sensors, temperature sensing, and other sensing elements. The apparatus includes a detector configured to sense the presence of an optional component of the apparatus, where the optional component is a valve configured to alter perfusion. Based on detection of the optional component, the controller switches between a first mode and a second mode.
In the first mode, the organ and pump self-regulate and control the perfusion circuit. In the second mode, clinician override of flow and/or pressure is enabled based on the presence of the optional valve/clamp component. The document also describes safety monitoring, including overpressure monitoring with automated pump and valve response behavior, as well as back-up sensing after a clamp adjustment via the sensors and detector.
Claims Coverage
The independent claim recites three main inventive areas: a perfusion circuit with a controller, a detector that senses an optional valve component and provides a presence signal, and controller mode switching between a first mode and a second mode based on whether the optional component is detected. The independent claim identifies the optional component specifically as a valve configured to alter perfusion.
Mode switching based on detection of an optional valve component
A detector detects an optional component of the apparatus and provides a signal to the controller indicative of the presence of the optional component, wherein the controller controls the perfusion circuit in a first mode when the optional component is detected and controls the perfusion circuit in a second mode when the optional component is not detected.
Optional valve configured to alter perfusion
The optional component is a valve configured to alter perfusion of the organ or tissue.
Controller configured to control the perfusion circuit
A controller is configured to control the apparatus, including control of the perfusion circuit during the first mode and the second mode.
Overall, the claim coverage is centered on a perfusion apparatus whose controller changes operating control modes depending on whether an optional valve component is detected, with the valve being configured to alter perfusion.
Stated Advantages
Provides clinician flexibility by allowing clinician control/override when the optional valve/clamp component is detected.
Provides back-up sensing after clamp adjustment via the pressure/flow and related sensors.
Provides safety via overpressure monitoring and automated pump/valve response behavior.
Documented Applications
Use in an organ perfusion apparatus with a perfusion circuit, including organ and tissue perfusion.
Use in transport/storage basin arrangements with an example transport/storage basin, cooling container, and disposable component considerations [procedural detail omitted for safety].
Use with bubble trap/oxygenator elements and associated sensors as part of the organ perfusion apparatus [procedural detail omitted for safety].
Interested in licensing this patent?