Sensor for the impedance measurements of the biological or chemical factor sample and the method for the detection of the biological or chemical factor in the sample using such a sensor
Inventors
Kupczunas, Artur • NIDZWORSKI, Dawid • URBANSKI, Krzysztof • MNICH, Jakub • PALA, Katarzyna • GONDEK, Tomasz • CZACZYK, Elzbieta • DZIABOWSKA, Karolina
Assignees
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Publication Number
US-12066395-B2
Publication Date
2024-08-20
Expiration Date
Abstract
The subject of the present invention is the sensor for the impedance measurements of the biological or chemical factor sample in the potentiostat system comprising the reference electrode RE and counting electrode CE with the electric contacts leading to the edge of the sensor in the form of the edge connector characterised in that it contains n working electrodes WEn, wherein n>2 and preferably n is in the range 2 to 256, and the reference electrode RE is common for all working electrodes WEn and the fragment thereof present by the working electrode WEn forms the measuring segment RE-CE-WEn. The subject of the invention is also the detection method of the chemical or biological factor in the sample using such a sensor.
Core Innovation
The invention relates to a sensor for impedance measurements of a biological or chemical factor sample in a potentiostat system. The sensor includes a reference electrode RE and a counting electrode CE with electric contacts leading to an edge of the sensor in the form of an edge connector, and the sensor comprises n working electrodes WEn, with n in a range of 2 to 256, wherein the reference electrode RE is common for all working electrodes WEn.
A fragment of the reference electrode RE is present by each working electrode WEn to form a measuring segment RE-CE-WEn. The edge connector comprises an HDMI port or a DisplayPort. This arrangement enables impedance measurements in a multi-working-electrode format while using a standardized connector interface at the edge of the sensor.
The invention also provides a method for detecting a biological or chemical factor in a sample suspension or solution. Sample placement covers working, counting, and reference electrodes, and 2 to 256 simultaneous impedance spectroscopy or voltammetry measurements are performed to determine the factor’s presence from the measurement results. The method further supports a reverse electrode configuration in which the reference electrode and counting electrode swap roles to obtain different impedance characteristics.
Claims Coverage
The patent includes one independent sensor claim and one independent detection method claim in the supplied claim set, together covering a multi-working-electrode potentiostat-compatible sensor hardware and simultaneous impedance/voltammetry-based factor detection, including a reverse electrode configuration. The independent claims specify the common reference electrode with measuring segments, the connector interface using HDMI or DisplayPort, the multi-electrode count range, and the simultaneous impedance spectroscopy/voltammetry detection framework.
Potentiostat sensor with common reference electrode and measuring segments
A sensor for impedance measurements in a potentiostat system comprising a reference electrode RE common for all working electrodes WEn, wherein a fragment thereof present by each working electrode WEn forms a measuring segment RE-CE-WEn, and the sensor comprises n working electrodes WEn with n in a range of 2 to 256.
Edge connector with HDMI or DisplayPort interface
An edge connector leading from electric contacts of the reference electrode RE and counting electrode CE, wherein the edge connector comprises an HDMI port or a DisplayPort.
Simultaneous impedance spectroscopy or voltammetry for detecting a biological or chemical factor
A method for detecting a biological or chemical factor by placing a sample so as to cover working, counting, and reference electrodes of the sensor and performing 2 to 256 simultaneous impedance spectroscopy or voltammetry measurements, then determining the factor’s presence from results.
Reverse electrode configuration swapping reference and counting roles
Conducting the measurements using a reverse electrode configuration where the reference electrode RE and the counting electrode CE swap roles.
Across the independent claims, the core coverage is a potentiostat-compatible multi-working-electrode impedance measurement sensor with a common reference electrode that forms measuring segments, an HDMI/DisplayPort edge connector interface, and a detection method based on 2 to 256 simultaneous impedance spectroscopy or voltammetry measurements to determine the presence of a biological or chemical factor, including measurement operation with a reverse electrode configuration.
Stated Advantages
Enables 2 to 256 simultaneous impedance spectroscopy or voltammetry measurements for detecting presence of a target biological or chemical factor.
Supports a reverse electrode configuration to obtain different impedance characteristics.
Documented Applications
Detection of lactose/beta-galactosidase using an impedance response described with reported impedance changes versus controls.
Detection/interrogation involving ssDNA complementary DNA interaction described with reported impedance changes versus controls.
H1N1 virus detection using antibody-modified copper electrodes, with reported impedance changes versus controls.
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