Matter of manufacture of compression legging system and associated uses
Inventors
Albaugh, Matthew • Argote, Pablo • Patel, Neal • Patel, Raj • Boppana, Sriram • Ocken, Alexander • Masquelin, Axel • Hoilett, Orlando • Miller, David • Drakopoulos, Michael
Assignees
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Publication Number
US-12063993-B2
Publication Date
2024-08-20
Expiration Date
Abstract
Described herein, is the manufacture, matter of compositions, function, methods and uses of a compression legging system that combines a swelling monitor, a patient activity monitor, medical compression legging material, and a mobile application to help PTS patients detect recurrent DVT and seek medical attention quickly before the development of PE, while reducing swelling and preventing DVT via compression therapy.
Core Innovation
The invention provides a system for detection of a human disease using a compression garment that includes a wearable sensor network and an application. The wearable sensor network includes a plurality of electrodes on each leg, where four electrodes are configured to be alternately activated in a configuration sequence of two current-injecting electrodes and two voltage-sensing electrodes. A multiplexor is configured to sequentially alternate which two electrodes are activated as the voltage-sensing electrodes, enabling data collection and data analysis from a plurality of different locations along each leg.
Bio-impedance measurements are collected for each location positioned between the two voltage-sensing electrodes, with a bio-impedance module configured to collect the measurements at those locations. The electrodes collect bio-impedance by delivering a plurality of current signals to each location between the voltage-sensing electrodes, where the plurality of current signals have varying current magnitudes. The delivered current signals are analyzed after passing through tissue at each location, producing bio-impedance measurements corresponding to multiple leg locations.
The compression garment further includes a central hardware unit connected to the at least one accelerometer-gyroscope module and the at least one bio-impedance module via wiring, textile electronic traces, or conductive connections. The central hardware unit supplies power, temporarily stores the bio-impedance measurements and an additional data set comprising acceleration and gyroscopic data, and transmits both to a mobile application. The mobile application receives a third data set from additional modules and transmits the bio-impedance measurements, the additional data set, and the third data set to an online server.
Claims Coverage
The document contains one independent claim directed to a disease-detection system, with dependent claims that narrow the disease set, garment types, and electrode and pressure configuration features. The independent claim centers on alternating activation of four electrodes in a multiplexed bio-impedance measurement scheme across multiple leg locations, combined with accelerometer-gyroscope data routed through a mobile application and an online server.
Multiplexed alternating four-electrode configuration for multi-location bio-impedance
Four electrodes of the plurality are configured to be alternately activated in each leg in a sequence of two current-injecting electrodes and two voltage-sensing electrodes, with a multiplexor sequentially alternating which two electrodes are activated as the voltage-sensing electrodes to enable data collection and data analysis from a plurality of different locations on each leg.
Central hardware unit for power, storage, and transmission of bio-impedance plus accelerometer-gyroscope data
The central hardware unit supplies power to the at least one accelerometer-gyroscope module and the at least one bio-impedance module; temporarily stores the bio-impedance measurements and the additional data set; and transmits the bio-impedance measurements and the additional data set to a mobile application, where the mobile application further transmits bio-impedance measurements, the additional data set, and a third data set to an online server.
Varying-current bio-impedance measurement of tissue between voltage-sensing electrodes
The bio-impedance module collects the bio-impedance measurements by delivering a plurality of current signals to each location positioned between the two voltage-sensing electrodes, with varying current magnitudes, and analyzes the plurality of delivered current signals after they pass through a section of tissue at each location between the voltage-sensing electrodes.
Dependent disease selection set and compression garment and electrode constraints
The dependent claims further define the system for detection of a disease selected from swelling, inflammation, post-thrombotic syndrome, deep vein thrombosis, venous injury, venous stasis, and pulmonary emboli, and add constraints including specific skin-contacting garment types, circular current-injecting band electrodes at distal and proximal ends, voltage-sensing electrodes positioned adjacent to each leg between corresponding current-injecting band electrodes, and electrode application pressure between 15 and 40 mmHg.
Overall, the claim coverage focuses on a compression garment with a multiplexed wearable electrode network that alternates current-injecting and voltage-sensing electrodes to obtain bio-impedance measurements at multiple leg locations, combined with accelerometer-gyroscope data that is transmitted through a mobile application to an online server. Dependent claims narrow the target disease set and specify garment types, electrode placement and configuration, and electrode application pressure.
Stated Advantages
Documented Applications
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