Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12059139-B2
Publication Date
2024-08-13
Expiration Date
Abstract
The invention regards a device for reconstituting a bioactive agent and forming a paste, the device comprising:—a container (2) containing the bioactive agent,—a first syringe (4) containing a liquid,—a second syringe (5) containing a paste forming material,—a connector element (6) configured for establishing sequential fluid connections between 1) the first syringe and the container, 2) the container and the second syringe, and 3) the first and second syringes, such that the liquid can be transferred from the first syringe to the container to reconstitute the bioactive agent, whereupon the reconstituted bioactive agent can be transferred from the container into the second syringe to form a paste, and the paste can be transferred to the first syringe.
Core Innovation
The invention provides a device for reconstituting a bioactive agent and forming a paste. The device comprises a container containing the bioactive agent, a first syringe containing a liquid, and a second syringe containing a paste forming material. A connector element establishes sequential fluid connections between the first syringe and the container, the container and the second syringe, and the first syringe and the second syringe, so the liquid is transferred from the first syringe to the container to reconstitute the bioactive agent.
After reconstitution, the reconstituted bioactive agent is transferred from the container into the second syringe to form a paste, and the paste is transferred to the first syringe. The connector element comprises at least a first valve and a second valve. The connector element provides at least a first arrangement providing simultaneous fluid passageway between the first syringe and the container and between the container and the second syringe, and a second arrangement providing a fluid passageway between the first syringe and the second syringe.
The invention further provides a method for reconstituting a bioactive agent and forming a paste using the described device elements. The method includes providing the first syringe with a first piston and the liquid, the container with the bioactive agent, and the second syringe with a second piston and the paste forming material, together with the connector element for sequential fluid connections. The method includes attaching the first syringe, the container, and the second syringe to the connector element, pushing the first piston to transfer liquid into the container and then transfer the reconstituted bioactive agent into the second syringe to form a paste, and mixing the paste by alternately pushing the second piston and the first piston such that the paste is transferred between the second syringe and first syringe.
Claims Coverage
The partial content identifies two independent claims: one directed to a device and one directed to a method. Across these claims, the main inventive features include sequential fluid connections among the first syringe, container, and second syringe; connector valve arrangements enabling different fluid-passage pathways; and mixing by alternating piston actuation to transfer the paste between syringes.
Sequential fluid connections for reconstituting and forming a paste
A device configured with sequential fluid connections between the first syringe and the container, the container and the second syringe, and the first syringe and the second syringe such that the liquid is transferred from the first syringe to the container to reconstitute the bioactive agent, and the reconstituted bioactive agent is transferred into the second syringe to form a paste and then to the first syringe.
Connector element with valve arrangements providing different fluid passageways
The connector element comprises at least a first valve and a second valve adapted to have a first arrangement providing simultaneous fluid passageway between the first syringe and the container and between the container and the second syringe, and a second arrangement providing a fluid passageway between the first syringe and the second syringe.
Alternately pushing pistons to mix by transferring paste between syringes
A method including mixing the paste by alternately pushing the second piston of the second syringe and the first piston of the first syringe such that the paste is transferred between the second syringe and first syringe.
Overall, the independent claims cover a connector-based device that performs sequential transfer for reconstitution and paste formation, connector valve arrangements that provide simultaneous passageways versus a passageway between the syringes, and a mixing approach that alternately pushes pistons to transfer the paste between syringes.
Stated Advantages
No manual measurements/weighing.
Self-contained predefined component ratios.
Faster and more reliable on-site paste preparation.
Reduced risk of erroneous mixing/sterility compromise.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?