Methods and devices for detection of THC
Inventors
Fotouhi, Mohammed • Abedi, Mehdi • Greenfield, Edward Alvin • Mollaaghababa, Reza • Taslim, Mohammad E.
Assignees
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Publication Number
US-12055543-B2
Publication Date
2024-08-06
Expiration Date
Abstract
In one aspect, a method of detecting tetrahydrocannabinol (THC) in a sample is disclosed, which comprises bringing the sample into contact with a graphene layer functionalized with an antibody exhibiting specific binding to THC, applying a time-varying electric field to said antibody-functionalized graphene layer, monitoring electrical resistance of said graphene layer in response to interaction with said sample, and detecting presence of THC in the sample by detecting a change in said electrical resistance indicative of interaction of THC with said anti-body functionalized graphene layer.
Core Innovation
The invention provides graphene-monolayer sensors functionalized with an antibody exhibiting specific binding to THC, wherein the graphene layer consists of a monolayer of carbon atoms. A sample is brought into contact with the antibody-functionalized graphene layer so that THC interaction with the antibody-functionalized graphene layer occurs.
The invention monitors at least one electrical property of the graphene layer in response to interaction with the sample. Detection of THC is performed by detecting a change in the electrical property indicative of interaction of THC with the antibody-functionalized graphene layer, including electrical resistance or related electrical property changes.
The invention further includes system configurations in which the graphene layer is deposited on a substrate and coupled to electrically conductive pads for measuring an electrical property. In additional embodiments, a sensing element is configured as a calibration sensing element, and the approach is extended to detecting THC analyte forms and metabolites, including Δ-9-THC and related forms, as well as CBD using antibodies exhibiting specific binding.
Claims Coverage
The document includes four independent claim scopes, two method claims and two system claims. Across them, the claims revolve around antibody-functionalized graphene monolayer sensors and measurements, with inventive features including specific THC binding, monitoring electrical property changes, a substrate and conductive pads configuration, and use of a calibration sensing element.
Antibody-functionalized graphene monolayer for THC specific binding
A method of detecting tetrahydrocannabinol (THC) in a sample, comprising bringing a sample into contact with a graphene layer functionalized with an antibody exhibiting specific binding to THC, wherein the graphene layer consists of a monolayer of carbon atoms.
Electrical property monitoring to detect THC interaction
Monitoring at least one electrical property of the graphene layer in response to interaction with the sample, and detecting presence of THC in the sample by detecting a change in the electrical property indicative of interaction of THC with the antibody-functionalized graphene layer.
Substrate with antibody-functionalized graphene monolayer and conductive pads
A system for detecting THC in a sample, comprising a sensor, comprising a substrate, a graphene layer deposited on a surface of the substrate, the graphene layer being functionalized with a plurality of antibodies exhibiting specific binding to THC, wherein the graphene layer consists of a monolayer of carbon atoms, and at least one pair of electrically conductive pads coupled to the antibody-functionalized graphene layer for measuring an electrical property of the antibody-functionalized graphene layer.
Calibration sensing element in THC detection system or method
A method of detecting tetrahydrocannabinol (THC) in a sample and configuring a sensing element as a calibration sensing element; and/or a system for detecting THC in a sample and a sensing element configured as calibration sensing element.
Overall, the claim coverage is centered on contacting a sample with an antibody exhibiting specific binding to THC on a graphene monolayer, monitoring an electrical property change indicative of THC-antibody interaction, measuring via conductive pads on a substrate-supported graphene monolayer, and using a sensing element configured as a calibration sensing element.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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