Dry powder inhaler with drug inlet mesh network
Inventors
Kang, Won Ho • CHOI, Youn Woong • Ha, Dae Chul • YANG, Seung Jin • YU, Gweon Hee • Nam, Kyu Yeol • JANG, Kyu Chul
Assignees
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Publication Number
US-12053574-B2
Publication Date
2024-08-06
Expiration Date
Abstract
The present invention relates to a dry powder inhaler. The dry powder inhaler includes an inhaler housing, a drug container configured to be provided in the inhaler housing and accommodate the dry powder drug, a drug inlet configured to be disposed above the drug container and through which the dry powder drug is inhaled, and a mesh network configured to be installed on a path of the drug inlet and have a mesh part for collision with the dry powder drug formed therein.
Core Innovation
The invention relates to a dry powder inhaler that maximizes lung delivery of a dry powder drug containing an active ingredient and a carrier. One or more mesh networks are placed along a drug inlet path so that the dry powder drug repeatedly collides with mesh parts during inhalation. The inhaler housing includes an outer housing and an inner housing, and a gap for air inflow is formed between the outer housing and the inner housing along the region between a first mesh network and a second mesh network.
The mesh networks include a first mesh network and a second mesh network, each having mesh parts for collision. The mesh parts are formed so that the first mesh network and second mesh network contribute to collision without overlapping spokes with respect to an inhaling direction. Alternately formed mesh parts are described such that different mesh sections have different hole sizes and/or densities, including alternately formed mesh parts with a cross-shaped mesh geometry and different hole densities.
To reduce attachment of active ingredient to the mesh, the mesh networks are described as being made of or coated with a water-soluble material. The dry powder drug is described with active ingredient and carrier powder particle-size ranges, and carriers include lactose. Example active ingredients described include fluticasone and salmeterol, as well as lung-cancer targeted drugs and insulin and GLP-related drugs.
Claims Coverage
The independent claim covers a dry powder inhaler with two mesh networks installed on a drug inlet path, where mesh parts collide with the dry powder drug while a housing arrangement forms an air inflow gap and provides a space for movement of a lever for actuation. The independent claim relies on three inventive features.
Two mesh networks along the drug inlet collision path
Mesh networks are installed on a path of the drug inlet, each having a mesh part for collision with the dry powder drug formed therein, and the mesh networks comprise a first mesh network and a second mesh network.
Non-overlapping spokes in inhaling direction
The first mesh network comprises a first circular rim and first spokes, and the second mesh network comprises a second circular rim and second spokes, where the first and second spokes are disposed such that the first spokes do not overlap with the second spokes with respect to an inhaling direction of the dry powder drug.
Outer and inner housings forming an air inflow gap between mesh networks
The inhaler housing comprises an outer housing including the first mesh network and an inner housing including the second mesh network accommodated in the outer housing, where the drug inlet is formed through the outer housing and the inner housing, and a gap for air inflow is formed between the outer housing and inner housing, the gap extending between the first mesh network and the second mesh network and providing a space for movement of a lever for actuation of the inhaler.
Overall, the claim coverage focuses on a dry powder inhaler in which two mesh networks are arranged along the drug inlet path to provide collision of the dry powder drug, with a spoke arrangement that does not overlap in the inhaling direction, and an outer/inner housing configuration that forms an air inflow gap extending between the mesh networks while also providing space for lever actuation.
Stated Advantages
Documented Applications
No documented applications found
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