Dynamic calibration of light intensity in a system for non-invasive detection of skin cancer using elastic scattering spectroscopy
Inventors
FREIDEN, Steven Ryan • MACCHI, Warren Stewart • SIMMONS, Cody Vance
Assignees
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Publication Number
US-12053263-B2
Publication Date
2024-08-06
Expiration Date
Abstract
Methods and devices are disclosed for calibrating intensity of a light source in a system of evaluating a skin lesion using Elastic-Scattering Spectroscopy (ESS). The ESS system may illuminate a sample of the skin lesion with a pulse from the light source adjusted to a high output setting, receive a signal comprising an elastic scattering spectrum from illuminating the skin lesion sample at the high output setting, determine whether the received signal has an intensity that is greater than a saturation threshold associated with at least one optical detection sensor, and if so, store the elastic scattering spectrum from illuminating the skin lesion sample at the high output setting. If not greater than the saturation threshold, the ESS system may illuminate the skin lesion sample with a pulse from the light source adjusted to a low output setting, receive a signal comprising an elastic scattering spectrum from illuminating the skin lesion sample at the low output setting, and store the elastic scattering spectrum from illuminating the skin lesion sample at the low output setting.
Core Innovation
The invention provides a dynamic intensity calibration for a skin-lesion evaluation system using Elastic-Scattering Spectroscopy (ESS). A sample of the skin lesion is illuminated with a first pulse from a light source adjusted to a high output setting, and an elastic scattering spectrum is received from the illuminated sample at the high output setting.
The system determines whether the received signal has an intensity greater than a saturation threshold associated with at least one optical detection sensor. If the received signal intensity is greater than the saturation threshold, the elastic scattering spectrum resulting from illuminating at the high output setting is stored. If the received signal intensity does not exceed the saturation threshold, the sample is illuminated with a second pulse adjusted to a low output setting and an elastic scattering spectrum at the low output setting is stored.
Normalized spectral data for the skin lesion is computed based on the stored elastic scattering spectrum and a reference sample signal. The reference sample signal is obtained from a reference sample elastic scattering spectrum acquired under the same output setting as used to generate the stored spectrum, and calibration parameters are defined in terms of high output up to a maximum output capability, a low output setting, and a saturation threshold preset based on sensor capability and tolerance.
Claims Coverage
Two independent claims are identified: one method claim and one system claim. Both center on adaptive selection of high versus low light-source output using a sensor saturation threshold and storage of corresponding elastic-scattering spectra, with normalized spectral data using a reference sample signal included in the method claim.
Dynamic intensity calibration using sensor saturation threshold
Illuminating a sample of the skin lesion with a first pulse adjusted to a high output setting, receiving an elastic scattering spectrum, determining whether the received signal intensity is greater than a saturation threshold associated with at least one optical detection sensor, storing the elastic scattering spectrum resulting from the high output setting if the intensity is greater than the saturation threshold, and otherwise illuminating with a second pulse adjusted to a low output setting and storing the low-output elastic scattering spectrum.
Normalized spectral data using reference sample signal
Computing normalized spectral data for the skin lesion based on the stored elastic scattering spectrum and a reference sample signal.
ESS system configured with voltage divider circuit and processor instructions for adaptive output
An ESS system comprising a light source, an optical detection sensor, a voltage divider circuit, and a processor coupled to memory with processor-executable instructions to illuminate a sample with a high output setting, receive an elastic scattering spectrum, determine whether received signal intensity is greater than a saturation threshold associated with at least one optical detection sensor, store the high-output spectrum when exceeded, and otherwise illuminate with a low output setting, receive the corresponding elastic scattering spectrum, and store the low-output spectrum.
The independent claims collectively cover an ESS approach that adaptively calibrates light-source intensity for skin-lesion evaluation by comparing received elastic-scattering signal intensity to a saturation threshold, storing the corresponding high- or low-output spectrum, and, in the method claim, computing normalized spectral data using a reference sample signal.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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