Portable oxygen source with perfusion system
Inventors
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12052986-B2
Publication Date
2024-08-06
Expiration Date
Abstract
The present disclosure includes a system to preserve tissue and associated methods. The system can include a portable oxygen source to provide oxygen and apply a pressure gradient to a flow of the oxygen, an organ preservation system having an inlet to fluidly couple to vasculature of the tissue, and an oxygen line to fluidly couple the portable oxygen source to the organ preservation system at the inlet, wherein the portable oxygen source is to apply the pressure gradient to pump fluid containing the oxygen through the organ preservation system.
Core Innovation
The invention relates to a system to preserve tissue that includes a portable oxygen source configured to simultaneously provide oxygen and to apply a pressure gradient to a flow of the oxygen. The portable oxygen source is coupled to an oxygen line that fluidly couples the portable oxygen source to an organ preservation system at an inlet, and the organ preservation system houses the tissue and has an inlet fluidly coupled to vasculature of the tissue for perfusing a fluid with oxygen.
The system further includes a compressed gas-powered pump coupled to the portable oxygen source. The portable oxygen source provides compressed oxygen to the compressed gas-powered pump, and the compressed gas-powered pump pumps a fluid containing oxygen to the organ preservation system. In this way, compressed oxygen is used to actuate pumping of oxygen-containing perfusate through the organ preservation system.
Embodiments describe transport/aviation use and system configurations including closed-circuit recirculating perfusion versus open single-pass perfusion. Optional additional components are described, including regulators, filters, a gas accumulator, an oxygenator, heat exchanger, pulse inducing or pulse modulating elements for pulsatile perfusate delivery, dialysis/waste removal, nutrient and drug infusion systems, and sensors and pressure relief.
Claims Coverage
The partial content includes two independent claims. Across the independent claims, the main inventive features comprise simultaneous oxygen provision and pressure-gradient application, oxygen line coupling into the organ preservation system, and compressed gas-powered pumping of oxygen-containing perfusate driven by compressed oxygen from the portable oxygen source.
Simultaneous portable oxygen and pressure gradient for oxygen flow
A portable oxygen source configured to simultaneously provide oxygen and to apply a pressure gradient to a flow of the oxygen.
Oxygen line coupling into tissue vasculature at an inlet
An organ preservation system for housing the tissue, having an inlet fluidly coupled to vasculature of the tissue; and an oxygen line to fluidly couple the portable oxygen source to the organ preservation system at the inlet and perfuse a fluid with the oxygen.
Compressed gas-powered pumping driven by portable compressed oxygen
A compressed gas-powered pump coupled to the portable oxygen source that provides compressed oxygen to the compressed gas-powered pump to pump the fluid containing the oxygen to the organ preservation system.
Portable oxygen source coupled to the gas-powered pump to apply a pressure gradient for perfusate
A compressed gas-powered pump coupled to the inlet to pump a perfusate to the organ preservation system; and a portable oxygen source coupled to provide oxygen to the perfusate and coupled to the compressed gas-powered pump to provide compressed oxygen to the compressed gas-powered pump to apply a pressure gradient to pump the perfusate containing oxygen to the organ preservation system.
The independent claims require an organ preservation system with an inlet coupled to tissue vasculature, oxygen delivery using a portable oxygen source via an oxygen line, and pumping of oxygen-containing perfusate using a compressed gas-powered pump driven by compressed oxygen supplied by the portable oxygen source.
Stated Advantages
Reduces or eliminates dedicated electrical/mechanical components by using a portable oxygen source as the energy source for pumping.
Allows transport/aviation use.
Provides safety advantages over high-pressure oxygen tanks.
Documented Applications
Transport use, including aviation.
Preserving tissue via oxygen-containing perfusate pumping into an organ preservation system.
Interested in licensing this patent?