Acoustic window for imaging and/or treatment of brain tissue
Inventors
BOUCHOUX, Guillaume • GODEFROY, Guillaume
Assignees
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Publication Number
US-12048585-B2
Publication Date
2024-07-30
Expiration Date
Abstract
The present invention relates to an acoustic window (1) suitable for implantation at an opening in a patient's skull (4), said acoustic window (1) being intended to cooperate with an external ultrasound probe (2) for the emission of ultrasound waves through the acoustic window (1), remarkable in that the acoustic window comprises a plate (11) including a plurality of through-holes (12), the distance (P) of the through-holes (12) being less than twice the wavelength of the ultrasound waves emitted by the external ultrasound probe (2).
Core Innovation
An acoustic window is configured to be implanted at an opening in a patient's skull and to cooperate with an external ultrasound probe for the emission of ultrasound waves through the acoustic window. The acoustic window comprises a plate and through-holes within the plate, and the plate stiffness is configured to satisfy a minimum deformation criterion that a force of 100 Newtons applied to the center of the plate generates a deformation of less than 5 millimeters.
The plate and the through-holes are configured to allow the transmission of ultrasound waves at angles greater than 20° relative to an angle of incidence normal to the plate. Transmission at these angles is enabled by wavelength-scaled constraints on the through-hole geometry, including a distance P between two adjacent through-holes that is less than five times the wavelength of the ultrasound waves emitted by the external ultrasound probe and a surface area covered by the through-holes that is greater than or equal to 50% of the total surface area of the plate.
A surgical implant set and a system for imaging and/or treating brain tissue are provided that include the acoustic window configured as implanted at a skull opening. The implant set comprises a package containing the window and instructions for use of the window as an acoustic window, and the system further includes an ultrasound-wave-generating probe cooperating with the implanted acoustic window for emission of ultrasound waves through the acoustic window.
Claims Coverage
The independent claims identified are clm-00001, clm-00018, and clm-00019, and they collectively define a mechanically stiff, acoustically transmissive implanted skull acoustic window with at-angle transmission criteria based on deformation under load and wavelength-scaled through-hole geometry. The independent claims cover the acoustic window structure, a packaged surgical implant set with instructions, and an imaging and/or treatment system using the acoustic window with an ultrasound-wave-generating probe.
Implanted acoustic window with stiffness-limited deformation
An acoustic window configured to be implanted at an opening in a patient's skull, cooperating with an external ultrasound probe for the emission of ultrasound waves through the acoustic window, wherein the acoustic window comprises a plate whose stiffness is configured to satisfy a minimum deformation criterion that a force of 100 Newtons applied to the center of the plate generates a deformation of less than 5 millimeters.
Wavelength-scaled through-hole geometry for transmission at >20°
An acoustic window wherein the plate and the through-holes satisfy criteria to allow the transmission of ultrasound waves at angles greater than 20° relative to an angle of incidence normal to the plate, wherein a distance P between two adjacent through-holes is less than five times the wavelength of the ultrasound waves emitted by the external ultrasound probe, and a surface area covered by the through-holes is greater than or equal to 50% of the total surface area of the plate.
Packaged surgical implant set with instructions for the acoustic window
A surgical implant set comprising a package, wherein the implant set comprises a window contained in the package, and instructions for use of the window as an acoustic window configured to be implanted at an opening in a patient's skull, said acoustic window cooperating with an external ultrasound probe for the emission of ultrasound waves through the acoustic window, wherein the acoustic window comprises a plate whose stiffness is configured to satisfy a minimum deformation criterion that a force of 100 Newtons applied to the center of the plate generates a deformation of less than 5 millimeters, and wherein the plate and the through-holes satisfy criteria to allow the transmission of ultrasound waves at angles greater than 20° relative to an angle of incidence normal to the plate.
Imaging and/or treating system using implanted acoustic window with ultrasound probe
A system for imaging and/or treating brain tissue including an ultrasound-wave-generating probe, wherein the system further comprises an acoustic window configured to be implanted at an opening in a patient's skull and cooperating with the ultrasound-wave-generating probe for the emission of ultrasound waves through the acoustic window, wherein the acoustic window comprises a plate whose stiffness is configured to satisfy a minimum deformation criterion that a force of 100 Newtons applied to the center of the plate generates a deformation of less than 5 millimeters, and wherein the plate and the through-holes satisfy criteria to allow the transmission of ultrasound waves at angles greater than 20° relative to an angle of incidence normal to the plate.
Across clm-00001, clm-00018, and clm-00019, the central claim coverage is the combination of a plate stiffness criterion based on deformation under a 100 Newton load with through-hole geometry that enables transmission of ultrasound at angles greater than 20° relative to normal incidence. The independent claims extend this to a packaged implant set with instructions and to a system for imaging and/or treating brain tissue using an ultrasound-wave-generating probe.
Stated Advantages
Allows the transmission of ultrasound waves at angles greater than 20° relative to an angle of incidence normal to the plate.
Satisfies a minimum deformation criterion such that a force of 100 Newtons applied to the center of the plate generates a deformation of less than 5 millimeters.
Provides an acoustic window for use with an external ultrasound probe for emission of ultrasound waves through the window when implanted at an opening in a patient's skull.
Documented Applications
An acoustic window configured to be implanted at an opening in a patient's skull for cooperating with an external ultrasound probe for the emission of ultrasound waves through the acoustic window.
A surgical implant set comprising a package and instructions for use of the window as an acoustic window configured to be implanted at an opening in a patient's skull.
A system for imaging and/or treating brain tissue that includes an ultrasound-wave-generating probe and an acoustic window implanted at an opening in a patient's skull for emitting ultrasound waves through the acoustic window.
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