Systems, methods, and devices for biomarker shaping and sleep profile enhancement
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Publication Number
US-12042606-B2
Publication Date
2024-07-23
Expiration Date
Abstract
Provided are systems, methods, and devices for biomarker shaping and sleep profile enhancement. Systems include a plurality of electrodes configured to be coupled to a brain of a user and configured to obtain a plurality of measurements from the brain of the user, and an interface configured to obtain the plurality of measurements from at least the plurality of electrodes. Systems also include a processing device comprising one or more processors configured to generate a first target sleep profile for the user based, at least in part, on the plurality of measurements and a plurality of biomarkers, the processing device being further configured to generate a plurality of stimulus parameters based, at least in part, on the target profile.
Core Innovation
The invention provides a system comprising a plurality of electrodes configured to be coupled to a brain of a user and configured to obtain a plurality of measurements from the brain. An interface obtains the plurality of measurements from at least the plurality of electrodes, and a processing device generates a first target sleep profile for the user based, at least in part, on the plurality of measurements and a plurality of biomarkers.
The first target sleep profile is identified based, at least in part, on a plurality of sleep stages and the plurality of biomarkers, where one or more biomarkers of the plurality of biomarkers identify each of the plurality of sleep stages. The first target sleep profile includes at least one target biomarker that corresponds with a sleep stage transition, and a comparison between the first target sleep profile and a sleep profile of the user is used to generate a plurality of electrical brain stimulus parameters.
The generated plurality of electrical brain stimulus parameters is configured to effect a change in a band ratio based on a range of values associated with a ratio of slow wave activity to beta wave activity, and based on the comparison of the first target sleep profile and the sleep profile of the user. In the method and device forms, the adjustment is expressed as changing a band ratio associated with the plurality of measurements to a target band ratio associated with the first target sleep profile.
Claims Coverage
The partial content includes three independent claims for a system, a device, and a method. Across the independent claims, the inventive coverage centers on generating a first target sleep profile from brain measurements and biomarkers, comparing the target sleep profile to a sleep profile of the user, and generating electrical brain stimulus parameters to adjust a band ratio toward a target band ratio associated with sleep stages and sleep-stage transitions.
Generating a first target sleep profile from measurements and biomarkers
Generate a first target sleep profile for the user based, at least in part, on the plurality of measurements and a plurality of biomarkers; the first target sleep profile is identified based, at least in part, on a plurality of sleep stages and the plurality of biomarkers, wherein one or more biomarkers identify each of the plurality of sleep stages.
Including target biomarker corresponding to sleep stage transition
The first target sleep profile includes at least one target biomarker that corresponds with a sleep stage transition.
Generating electrical brain stimulus parameters to adjust a band ratio
Generate a plurality of electrical brain stimulus parameters to effect a change in a band ratio based on a range of values associated with a ratio of slow wave activity to beta wave activity based, at least in part, on a comparison of the first target sleep profile and a sleep profile of the user; in the method and device forms, adjust a band ratio associated with the plurality of measurements to a target band ratio associated with the first target sleep profile.
Using a controller-generated control signal for stimulus parameters
Generate a control signal based on the plurality of stimulus parameters; in the method form, generate, using a controller, a control signal based on the plurality of stimulus parameters and use the control signal to stimulate the brain of the user via the plurality of electrodes based on the plurality of stimulus parameters.
The independent claims cover deriving a first target sleep profile from brain measurements and biomarkers mapped to sleep stages, including biomarkers corresponding to sleep stage transitions; comparing the target sleep profile to a sleep profile of the user; and generating electrical brain stimulus parameters that adjust a band ratio related to slow wave activity and beta wave activity toward a target band ratio, with controller control-signal generation and use in the device and method claims.
Stated Advantages
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