Methods and systems for draining cerebrospinal fluid into the venous system

Inventors

HEILMAN, Carl • Malek, Adel M. • Rezac, David A. • Robinson, Timothy W. • Ting, Joseph

Assignees

Cerevasc Inc

Abstract

Methods for treating hydrocephalus using a shunt, the shunt having one or more CSF intake openings in a distal portion, a valve disposed in a proximal portion of the shunt, and a lumen extending between the one or more CSF intake openings and the valve, the method comprises deploying the shunt in a body of a patient so that the distal portion of the shunt is at least partially disposed within a CP angle cistern, a body of the shunt is at least partially disposed within an IPS of the patient, and the proximal portion of the shunt is at least partially disposed within or proximate to a JV of the patient, wherein, after deployment of the shunt, CSF flows from the CP angle cistern to the JV via the shunt lumen at a flow rate in a range of 5 ml per hour to 15 ml per hour.

Core Innovation

The invention describes endovascular treatment of hydrocephalus, pseudotumor cerebri, and intracranial hypertension by accessing a cerebrospinal fluid (CSF)-filled intracranial subarachnoid space (SAS) from a venous sinus and forming an anastomosis between the venous sinus and the SAS. A delivery catheter includes a deflecting element configured to deflect a tissue penetrating member toward a target penetration site in a wall of the venous sinus, and a stabilizing member engages the venous sinus wall to stabilize a distal end portion of the delivery catheter proximate the target penetration site.

An implant is advanced through and deployed from the delivery catheter, with an implant distal portion having a distal anchoring mechanism configured for securing the implant distal portion within the SAS. The implant further includes an implant lumen in fluid communication with one or more distal openings in the implant distal portion and with one or more proximal openings in the implant proximal portion, providing fluid communication between the SAS and the venous side while preventing back flow of venous blood into the SAS and regulating CSF flow.

In another embodiment, the system includes a conduit having a tubular configuration with a conduit proximal portion, a conduit distal portion, and a conduit lumen extending between openings. The conduit is configured for deployment in a venous sinus proximate a target penetration site in a wall of the venous sinus adjacent the SAS, and the conduit is configured to house the implant when deployed. A tissue penetrating element creates the anastomosis through the venous sinus wall to access the SAS.

Claims Coverage

The independent claims cover 4 inventive features. They address a delivery catheter that accesses a CSF-filled intracranial subarachnoid space (SAS) from a venous sinus using a deflecting element and a stabilizing member, an implant secured by a distal anchoring mechanism with an implant lumen providing fluid communication through distal and proximal openings, a conduit deployed in the venous sinus adjacent the SAS that houses the implant, and a tissue penetrating element that creates the anastomosis through the venous sinus wall.

Overall, the independent claims broadly cover endovascular systems that create a venous sinus-to-SAS anastomosis using a delivery catheter and a stabilized access mechanism, and that deploy an implant secured within the SAS by a distal anchoring mechanism while providing luminal fluid communication through distal and proximal openings. They further cover embodiments in which a venous-sinus-deployed conduit houses the implant adjacent the SAS, while a tissue penetrating element creates the anastomosis through the venous sinus wall.

Stated Advantages

Documented Applications

No documented applications found