Composition comprising a mixture of molecules extracted from Chrysanthellum indicum, Cynara scolymus and Lycium barbarum and use to act on carbohydrate and/or fat metabolism
Inventors
Peltier, Sebastien • Chavanelle, Vivien • Sirvent, Pascal
Assignees
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Publication Number
US-12011474-B2
Publication Date
2024-06-18
Expiration Date
Abstract
A composition comprising at least a mixture of molecules extracted from Chrysanthellum indicum, Cynara scolymus and Lycium barbarum. This composition is in particular useful as a nutritional product or health product to prevent and/or combat fat and/or carbohydrate metabolism disorders in Humans or animals.
Core Innovation
The invention relates to a multi-target composition in dosage forms including a tablet, capsule, powder, gel, emulsion or liquid, comprising a mixture of Chrysanthellum indicum extract, Cynara scolymus extract, and Lycium barbarum extract, together with an extract selected from piperine, Piper extract, Olea europeae extract, Vaccinium myrtillus extract, or any combination thereof. The Chrysanthellum indicum extract, the Cynara scolymus extract and the Lycium barbarum extracts are present in a ratio from 0.001:0.001:0.001 to 10:10:10, respectively.
The composition acts on fat metabolism and carbohydrate metabolism as a multi-target approach. The problem addressed is the prevention and/or combat of cardio-metabolic disorders, including dyslipidemia, obesity/metabolic syndrome, and hypertension, and improving insulin sensitivity and fasting blood glucose. The composition is described as lowering levels of low-density lipoprotein cholesterol and triglycerides in blood.
The disclosed evidence includes in vivo mouse data using db/db models showing reduced total cholesterol and LDL cholesterol, reduced triglycerides, improved insulin sensitivity, and reduced fasting blood glucose, with metformin used as a comparison. The document also reports synergy between Chrysanthellum indicum and Cynara scolymus using a Colby SR method with synergy factors, and reduced hepatic triglycerides for the full three-plant combination.
Claims Coverage
The independent claim covers dosage forms for lowering low-density lipoprotein cholesterol and triglycerides in a human using a therapeutically effective mixture of three specific plant extracts in a defined ratio range, optionally combined with a selected additional extract. The inventive features are centered on the specified extract set and ratio limits, and on restricting the composition to consist essentially of the listed components.
Lowering LDL cholesterol and triglycerides with multi-plant extract mixture
A tablet, capsule, powder, gel, emulsion or liquid for lowering levels of low-density lipoprotein cholesterol and triglycerides in the blood of a human, consisting essentially of a therapeutically effective amount of a mixture of a Chrysanthellum indicum extract, a Cynara scolymus extract, a Lycium barbarum extract, and an extract selected from the group consisting of piperine, Piper extract, Olea europeae extract, Vaccinium myrtillus extract and any combination thereof.
Defined extract ratio range for the three primary extracts
The Chrysanthellum indicum extract, the Cynara scolymus extract and the Lycium barbarum extracts are in a ratio from 0.001:0.001:0.001 to 10:10:10, respectively.
Overall, the claim coverage is centered on a consist essentially of multi-extract composition in defined dosage forms for lowering LDL cholesterol and triglycerides, using a specific Chrysanthellum indicum/Cynara scolymus/Lycium barbarum extract ratio range and an additional selected extract chosen from piperine, Piper extract, Olea europeae extract, Vaccinium myrtillus extract, or combinations.
Stated Advantages
Lowering levels of low-density lipoprotein cholesterol and triglycerides in blood.
Prevention and/or combat of cardio-metabolic disorders including dyslipidemia, obesity/metabolic syndrome, and hypertension.
Improving insulin sensitivity and fasting blood glucose.
Demonstrated synergy between Chrysanthellum indicum and Cynara scolymus using a Colby SR method.
Reduction of total cholesterol and LDL cholesterol, and reduction of triglycerides in db/db mouse models.
Reduced hepatic triglycerides for the full three-plant combination.
Documented Applications
Therapeutic use as a tablet, capsule, powder, gel, emulsion or liquid for treating a human with a specified pathological disorder by administering the composition.
Treatment methods include pathological disorders associated with diabetes and cardio-metabolic conditions, including dyslipidemia, type 1 diabetes, type 2 diabetes, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, coronary cardiopathy, cerebrovascular disease, peripheral ateriopathy, and deep vein thrombosis.
Combination therapy in which the composition is administered together with a therapeutic agent selected from specified lipid-modulating drugs.
Combination therapy in which the composition is administered together with an antidiabetic therapeutic agent selected from a specified list.
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