Dry powder inhaler and system for drug delivery
Inventors
Smutney, Chad C. • Kinsey, P. Spencer • Sahi, Carl R. • Adamo, Benoit • Polidoro, John M. • McLean, Scott • Overfield, Dennis • Bryant, Anthony
Assignees
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Publication Number
US-11998683-B2
Publication Date
2024-06-04
Expiration Date
Abstract
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.
Core Innovation
An inhaler is described that includes a housing, and a mouthpiece having an oral placement section and an extended portion. The extended portion extends from the oral placement section and is configured as a cover that extends over and engages the housing by a locking mechanism. The inhaler further includes a gear mechanism and a sled including a cartridge holder.
When the gear mechanism is actuated, it moves the sled in a concurrent movement within the housing. The movement translocates a cartridge comprising a container, both in the cartridge holder, from a powder containment position to a dosing position.
In the dosing position, the inhaler is configured such that 10% to 70% of total airflow through the inhaler enters and exits the cartridge. The described configurations relate the mechanical translocation of the cartridge with the airflow fraction entering the cartridge in the dosing position.
Claims Coverage
The document includes two independent claims, which share a common inhaler architecture and differ in the translocation from containment to dosing position and the airflow fraction entering and exiting the cartridge in the dosing position. Across the dependent claims, the main inventive constraints are concentrated on the cartridge contents and on particular implementations of the mouthpiece-to-housing locking mechanism.
Cartridge translocation by a gear-driven sled within a housing
An inhaler comprising a housing, a mouthpiece with an extended portion configured as a cover that engages the housing by a locking mechanism, a gear mechanism, and a sled including a cartridge holder; wherein actuation of the gear mechanism moves the sled in a concurrent movement within the housing and wherein the movement of the sled is configured to translocate a cartridge comprising a container, both in the cartridge holder, from a powder containment position to a dosing position.
Airflow fraction entering and exiting the cartridge in the dosing position
An inhaler comprising a housing; a mouthpiece with an oral placement section and an extended portion configured as a cover that extends over and engages the housing by a locking mechanism; a gear mechanism; and a sled including a cartridge holder; wherein actuation of the gear mechanism moves the sled to translocate a cartridge in the cartridge holder from a containment position to a dosing position, and wherein in the dosing position 10% to 70% of total airflow through the inhaler enters and exits the cartridge.
Overall, the claim set covers an inhaler in which a gear mechanism actuates a sled to translocate a cartridge from a powder containment position to a dosing position, with the dosing position further characterized by a defined fraction of total airflow entering and exiting the cartridge. Dependent claims refine the cartridge contents toward dry powder medicaments containing at least one active ingredient, including peptide/protein-type active ingredients and diketopiperazine, and specify a particular form of the locking mechanism.
Stated Advantages
Documented Applications
Not explicitly described in patent.
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