Collecting components of a fluid
Inventors
Bainbridge, Marlene • Green, Todd Curtis • FENDER, Logan
Assignees
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Publication Number
US-11994509-B2
Publication Date
2024-05-28
Expiration Date
Abstract
Embodiments are described for separating collecting components from a multi-component fluid such as whole blood. Some embodiments provide for controlling the amount of a component, such as platelets, introduced into a separation chamber to ensure that the density of fluid in the separation chamber does not exceed a particular value. This may provide for collecting purer components. Other embodiments may provide for determining a chamber flow rate based on a concentration of a component in the multi-component fluid, which may then be used to determine a centrifuge speed, to collect purer concentrated components.
Core Innovation
The disclosed invention relates to separating whole blood into components by rotating a centrifuge and using a first separation chamber in which a first composite fluid is separated into at least a first component and a second component by subjecting the first composite fluid to a first centrifugal field created by the centrifuge rotating at a first centrifuge speed. During the separating, an amount of at least one of the first component and the second component is maintained in the first separation chamber below a predetermined amount.
A processor receives either an indication of a first collection procedure for collecting a first product from whole blood or an indication of a second collection procedure for collecting a concentrated product from the whole blood. In the first collection procedure, first data related to a first amount of a first component in the whole blood is received and a depletion in the amount of the first component in the whole blood from the first source is determined, and in response the processor changes the first flow rate to introduce the whole blood into the first separation vessel at a second flow rate.
In the second collection procedure, the processor determines a second chamber flow rate based on the first data and determines a second centrifuge speed based on the second chamber flow rate. The processor rotates the centrifuge at the second centrifuge speed, introduces a second composite fluid into the first separation chamber at the second chamber flow rate, separates the second composite fluid using a second centrifugal field created by the centrifuge rotating at the second centrifuge speed, and collects the first component of the second composite fluid to form the concentrated product.
Claims Coverage
The partial content provides three independent claims: a method claim, a separation device claim, and another method claim. Across the independent claims, there are multiple inventive features centered on processor-controlled centrifugation in a separation chamber, maintaining component amounts below a predetermined amount, determining depletion, and adjusting flow rate and centrifuge speed based on received data and chamber flow rate.
Processor indication driven selection of collection procedure
Receiving, by at least one processor, either a first indication of a first collection procedure for collecting a first product from whole blood or a second indication of a second collection procedure for collecting a concentrated product from the whole blood.
Maintain component amount below predetermined limit during separation
During the separating, maintaining an amount of at least one of the first component of the first composite fluid and the second component of the first composite fluid in the first separation chamber below a predetermined amount.
Depletion determination and flow-rate change responsive to depletion
Determining a depletion in the amount of the first component in the whole blood from the first source and changing, in response to determining the depletion, the first flow rate to introduce the whole blood into the first separation vessel at a second flow rate.
Determine chamber flow rate and centrifuge speed for concentrated product mode
Determining a second chamber flow rate based on the first data and determining a second centrifuge speed based on the second chamber flow rate, then rotating the centrifuge at the second centrifuge speed and collecting the first component of the second composite fluid to form the concentrated product.
Centrifuge-processor-memory separation device implementing processor-controlled control
A separation device comprising a centrifuge, a processor coupled with the centrifuge, and a memory storing instructions executable by the processor to receive an indication of a first or second collection procedure, control centrifuge rotation and introduce whole blood and composite fluid into a separation chamber, maintain component amounts below a predetermined amount, determine depletion and change the flow rate, and form the first product and concentrated product.
Portion-based depletion measured in whole blood portion
Determining a depletion in the amount of the first component of the first composite fluid measured in the first portion of the whole blood and changing, in response to determining the depletion in the amount measured in the first portion, the first flow rate to introduce the first portion into the first separation vessel at a second flow rate.
The independent claims collectively cover processor-driven selection between a first collection procedure and a second collection procedure, separation of composite fluid in a separation chamber under centrifugal fields while maintaining component amounts below a predetermined amount, depletion determination that triggers changing whole-blood introduction flow rate, and a concentrated-product mode in which chamber flow rate and centrifuge speed are determined based on received data.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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