Intelligent pharmaceutical delivery system with non-concentric pumping mechanism to reduce flow anomaly and method of using
Inventors
Bibian, Stéphane • Barua, Sankar • Zikov, Tatjana
Assignees
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Publication Number
US-11986627-B1
Publication Date
2024-05-21
Expiration Date
Abstract
The present invention relates to titration and delivery of anesthetic and sedative medications to a subject. Further, the present invention relates to a device and methods for titrating and delivering the medications in a semi-automated or fully automated manner and which can be monitored and controlled remotely. Even still further, the present invention relates to the device that can perform the titration and the delivery of the medications in a manner that minimalizes occlusion and prevents back flow of the medications. More particularly, the present invention relates to the device for the titration and the delivery of the medications using a non-concentric pumping mechanism that gradually or progressively increases and decreases occlusion in a medication delivery line within the pumping mechanism to minimize and/or prevent sudden formation and release of the occlusion in order to provide more steady and continuous flow of the medications through the device to the subject.
Core Innovation
The invention is a system for delivering intravenous drugs and fluids to a subject using an infusion pump and a controller that performs real-time quantitative monitoring of a physiological signal. The infusion pump includes an administration set integrating a disposable cartridge with rollers or roller elements, gears, a tube, and a pumping chamber having an entry opening, an exit opening, and a tubing groove. The tubing groove has a groove wall with a non-concentric geometry, and the non-concentric groove geometry is adapted to reduce flow pulsation and occlusion of the infusion pump.
The pump module includes a driving shaft adapted to cause the gears to rotate and is adapted to allow insertion and locking of the disposable cartridge into place. The infusion pump is adapted to progressively increase the occlusion at or near the entry opening and progressively decrease the occlusion at or near the exit opening, and this progressive occlusion behavior is arranged to reduce the flow pulsation.
The system uses a physiological signal sensor adapted to acquire a physiological signal from the subject, and the controller includes a processor that receives the physiological signal and executes an algorithm for real-time quantitative monitoring. The controller is adapted to control the infusion pump and administration of the intravenous drugs and fluids based on the monitored physiological signal.
Claims Coverage
The provided independent claims are clm-00001 and clm-00011. They center on a non-concentric roller/gear infusion pump architecture with progressive occlusion behavior and a controller that performs real-time quantitative monitoring of a physiological signal from a sensor to control intravenous drug and fluid delivery; clm-00011 further specifies an occlusion limit at the exit opening.
Non-concentric roller-occlusion infusion pump geometry for reduced pulsation
An infusion pump comprising an administration set integrating a disposable cartridge with at least two rollers or roller elements, gears, a tube, and a pumping chamber having an entry opening, an exit opening, and a tubing groove having a groove wall with a non-concentric geometry, wherein the tube is occluded by a passage of the at least two rollers or roller elements, and wherein the non-concentric groove geometry is such that a distance between each of the at least two rollers or roller elements and the groove wall is adapted to reduce flow pulsation and occlusion.
Progressive occlusion at entry and exit to reduce flow pulsation
The infusion pump is adapted to progressively increase the occlusion at or near the entry opening and progressively decrease the occlusion at or near the exit opening to reduce the flow pulsation.
Real-time quantitative physiological-signal monitoring and pump control
A physiological signal sensor adapted to acquire a physiological signal from the subject; and a controller comprising a processor adapted for receiving the physiological signal from the physiological signal sensor and further comprising an algorithm adapted to perform real-time quantitative monitoring of the physiological signal, wherein the controller is adapted to control the infusion pump and administration of the intravenous drugs and fluids.
Progressive occlusion with maximum exit occlusion level
The infusion pump is adapted to progressively increase the occlusion at or near the entry opening and progressively decrease the occlusion at or near the exit opening to reduce the flow pulsation and wherein the occlusion at or near the exit opening is at most 20% of a maximum occlusion level in the tube.
Across the independent claims, the inventive concept combines a non-concentric roller/gear infusion pump architecture adapted to reduce flow pulsation, a progressive occlusion profile increasing near the entry opening and decreasing near the exit opening, and a controller that uses real-time quantitative monitoring of a physiological signal acquired by a sensor to control intravenous drug delivery. Independent claim clm-00011 further specifies that the occlusion near the exit opening is at most 20% of a maximum occlusion level.
Stated Advantages
Reduce flow pulsation and occlusion of the infusion pump.
Reduce flow pulsation by progressively increasing occlusion at or near the entry opening and progressively decreasing occlusion at or near the exit opening.
Documented Applications
Deliver intravenous drugs and fluids to a subject.
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