Devices, systems and methods for surface sampling

Inventors

Adolphson, Alec D. • Packingham, Ann K. • Page, Andrew E. • Alburty, David S. • Packingham, Zachary A. • Birkenholz, John D. • Fischer, Michael F.

Assignees

Innovaprep LLC

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Publication Number

US-11986168-B2

Patent

Publication Date

2024-05-21

Expiration Date


Abstract

Devices, systems and methods are disclosed which relate to using wet foam elution for removal of particles from swabs and wipes. This allow users to capture particles from surfaces and recover them by elution into small sample volumes for subsequent detection for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required. More specifically, the swabs or wipes are used to collect samples in the standard ways that commercially available swabs and wipes are in use today; from, for instance, food preparation surfaces in food plants, from production equipment in pharmaceutical facilities, for collection of dry powders during bioterrorism event response, and for collection of clinical samples such as nasal, throat, nasopharyngeal, and wounds.

Core Innovation

The invention provides a portable system for collecting and extracting a sample from a surface using a swab having a head at one end of an extended shaft with a lumen extending substantially throughout the shaft length. A portable canister contains pressurized wet foam, and a cradle houses the canister with a canister valve actuator connected to the cradle. A dispensing lever connected to the canister valve actuator drives actuation so that the canister valve actuator presses on the valve stem on the pressurized canister.

When the dispensing lever is pressed, pressurized wet foam is introduced at an opposite end of the extended shaft relative to the head. The wet foam travels through the lumen and elutes samples from the head, implementing a wet-foam elution extraction mechanism within a portable swab format.

The document further describes foam-elution flow modes and system configurations, including distributing foam through the lumen and out through the swab head, with refinements such as shaft apertures or a porous shaft section near the head. Other embodiments describe wet foam flowing across the swab head exterior and collecting eluted wet-foam sample in a collection receptacle, with controlled foam dispensing using valves and optional swab ejection.

Claims Coverage

The partial content includes one independent claim, clm-00001, directed to a portable swab-based sample collection and extraction system using pressurized wet foam delivered through a swab lumen. The independent claim is refined by dependent claims that add structural and flow-control features, including head-side apertures or porous sections, a collection receptacle, orifice flow control, electromechanical volume control, and canister constituent limitations.

Portable swab with lumen for pressurized wet-foam elution

A swab having a head at one end of an extended shaft, the extended shaft having a lumen that extends substantially throughout the length of the shaft; pressurized wet foam is introduced at an opposite end of the extended shaft with respect to the head; the wet foam travels through the lumen and elutes samples from the head.

Pressurized wet-foam canister actuator linked to a dispensing lever

A portable canister having a valve stem and containing pressurized wet foam; a cradle for housing the canister; a canister valve actuator connected to the cradle; and a dispensing lever connected to the canister valve actuator, wherein upon pressing of the dispensing lever, the canister valve actuator presses on the valve stem on the pressurized canister.

Apertures for uniform foam distribution through the swab head

The extended shaft includes apertures near the head to enable uniform distribution of wet foam through the head and over its exterior surface.

Collection receptacle for collecting eluted wet-foam sample

A collection receptacle collects the wet foam sample after elution from the swab head.

Orifice in canister valve stem for flow control

An orifice in the canister valve stem controls the flow of liquid exiting the canister.

Electromechanical valve controlling foam volume

An electromechanical valve controls the volume of foam dispensed.

Canister composition of water with surfactant, buffer, and water-soluble gas

The canister contains water together with a surfactant, a buffer, and a water-soluble gas.

Across the independent claim and its refinements, the core claim coverage centers on a portable swab with a lumen enabling pressurized wet-foam travel and sample elution from the swab head, actuated via a canister valve actuator and dispensing lever. Dependent features further specify how foam is distributed near the head, how eluted sample is collected, and how foam output is controlled via an orifice and electromechanical volume control, with canister constituents defined as water, surfactant, buffer, and a water-soluble gas.

Stated Advantages

Expanded fluid volume enabling efficient elution at reduced sample volumes.

Improved target concentration.

Documented Applications

Clinical, veterinary, food safety, pharma, outbreak/forensics, biodefense, and environmental monitoring use cases for recovering particles from swabs and surface wipes using wet-foam elution to produce small-volume eluates for downstream detection.

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