System and methods for developing and using a microbiome-based action component
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Publication Number
US-11978543-B2
Publication Date
2024-05-07
Expiration Date
Abstract
The invention relates generally to a system and methods by which a microbiome-based action component may be developed that is useful in order to establish, restore, promote, or maintain subject health. More specifically, the system and methods of the present invention may be used to develop a microbiome-based action component that efficiently summarizes the state of a subject's microbiome along with measures of gut maturity in case of an infant and nutrition readiness in case of an adult subject. Such an efficient summary may be used to render more immediate support or health care to the subject. Certain specific embodiments of the present invention may be used to facilitate the development a microbiome-based action component that provides, in addition to the efficient summary, a subject-specific, personalized microbiome health plan that includes options that may be followed in order that the subject may achieve personal health, growth, and development goals given the state of the subject's microbiome and state of maturity or nutritional readiness by aligning appropriate decision-making to the individual microbiome-based profile of the subject.
Core Innovation
The invention relates to a computer program that generates a profile identifying a state of a subject gut microbiome and gut maturity using a gut microbiome maturity measure (GM3). The program accesses GM3 information of a subject, where the GM3 information consists of categories including non-modifiable risk factors, modifiable risk factors, perinatal and maternal risk factors, and microbiome-based measures of gut status. The invention transforms the accessed GM3 information into a gut maturity/readiness profile of the state of the subject gut microbiome and gut maturity.
The transforming step includes providing, by a processor, an equation GM3 value = f1w1 + f2w2 + f3w3 + fx wx, where f is a factor within the categories of the GM3 information and w is a weight value. Each weight value corresponds to an impact of the factor on a GM3 score, and the processor calculates a subject GM3 value using the GM3 information. The calculated GM3 value is used as the center element in a graphical user interface that summarizes the subject’s gut maturity/readiness profile.
The graphical user interface displays a plurality of charts and a plurality of concentric circles, including a center circle that includes the calculated subject GM3 value. The user interface further includes annuli with pie chart elements and factors identified in the concentric circles, where the size of each pie chart element is representative of the weight value of the corresponding factor on the GM3 value. The charts include a bar chart with a y-axis representing a feed rate value and color-represented feed types, and a bar graph with a y-axis representing a proportion value of microbiota types, and the gut maturity/readiness profile is configured to assist decision making relating to nutrition or care for the subject.
Claims Coverage
Independent claim clm-00001 covers a computer program that transforms GM3 category information into a subject-specific gut maturity/readiness profile using a weighted GM3 equation and presents the resulting profile via a graphical user interface with concentric circles and multiple charts. Dependent refinements add specific visualization elements and protocol selection or communication functionality.
Weighted GM3 equation transformation into a gut maturity/readiness profile
Transforming GM3 information into a gut maturity/readiness profile of the state of the subject gut microbiome and gut maturity, wherein the transforming step provides an equation GM3 value = f1w1 + f2w2 + f3w3 + fx wx, f is a factor within the categories of the GM3 information, w is a weight value corresponding to an impact of the factor on a GM3 score, and calculating a subject GM3 value using the GM3 information of the subject.
Concentric-circle graphical user interface summarizing subject gut maturity/readiness
Displaying a graphical user interface summarizing a state of the subject's gut maturity/readiness profile, wherein the graphical user interface comprises a plurality of charts and a plurality of concentric circles, including a center circle that includes a calculated subject GM3 value and annuli that identify the factors with pie chart elements sized by the corresponding weight value and including bar chart elements representative of an impact of the factor on the calculated subject GM3 value.
Feed-rate bar chart with color-represented feed types and microbiota proportion bar graph
Displaying, in the graphical user interface, a bar chart and a bar graph on a common x-axis representing a number of days of life, wherein the bar chart has a y-axis representing a feed rate value with first rectangles whose segments include height representative of feed rate value and color representative of feed type comprising breast milk (MBM), donor's breast milk (DBM), or formula (FORM), and wherein the bar graph has a y-axis representing a proportion value of a microbiota with second rectangles whose portions include height representative of a value for a proportion of the type of microbiota and color identifying a type of microbiota.
Microbiota for age Z-score line chart visualization
Including a line chart titled “Microbiota for Age Z-Score” that plots Z-scores for a subject’s microbiota over age, wherein the line chart has a y-axis representing Z-score values and includes a plurality of points derived from microbiota values relative to the mean of ‘healthy’ subjects at the same age and day of life.
Gut community type stage indication via second y-axis
Including a line chart with a second y-axis that represents gut community types (GCT) and indicates a stage of a gut community type.
Non-modifiable risk factors include mode of birth, chronological age/gestational age, and gastrointestinal disease
For non-modifiable risk factors identified in a second annulus, the factors include mode of birth, chronological age or gestational age at birth for a preterm infant, and gastrointestinal disease.
Perinatal and maternal risk factors include maternal diet, maternal BMI, perinatal steroid and antibiotic exposure, and maternal age
For a perinatal and maternal risk factors category, the second annulus includes factors of maternal diet, mother body mass index (BMI), perinatal steroid and antibiotic exposure, and maternal age.
Protocol selection based on gut maturity/readiness profile with optional aural communication
Selecting, based on a gut maturity/readiness profile, one protocol from multiple protocols and then displaying the protocol or communicating it aurally.
Overall, the claim set centers on computing a subject GM3 value from categorized factors using a weighted equation and using that value in a concentric-circle graphical user interface with multiple charts that support decision making relating to nutrition or care. Dependent refinements add specific microbiota and gut community type visualizations, specify examples of factors in the annuli, and extend functionality to selecting a protocol from multiple options with optional aural communication.
Stated Advantages
Assists decision making relating to nutrition or care for the subject.
Documented Applications
Generating and displaying a gut maturity/readiness profile to assist decision making relating to nutrition or care for the subject.
Selecting a nutrition or care protocol from multiple protocols based on the gut maturity/readiness profile, with optional display or aural communication.
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