Multi-dose medicament delivery device
Inventors
Boyes, Robert Nichol • Braithwaite, Philip Wilson
Assignees
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Publication Number
US-11969547-B2
Publication Date
2024-04-30
Expiration Date
Abstract
There is described a multi-unit dose dry powder medicament delivery device comprising: a first element comprising a single use nozzle located in a body which is at least partially lined with an inner member, said inner sleeve comprising an airway and a cartridge seat; and a second element adapted to be releasably attached to the first element, said second element comprising an actuator provided with an air source and a valve.
Core Innovation
The invention provides a multi-unit dose dry powder medicament delivery device. The device comprises a first element having a single use nozzle located in a body at least partially lined with an inner sleeve, and the inner sleeve includes an airway and a cartridge seat for interaction with a medicament container for delivery of dry powder medicament.
A second element is adapted to be releasably attached to the first element and includes an actuator provided with an air source and a valve. The inner sleeve is provided with a shuttle valve dimensioned such that in the closed position it blocks the airway only until the device is primed by a user, and the shuttle valve includes two orifices while the nozzle is provided with a stop capable of arresting movement of the shuttle valve.
The actuator includes a spigot element that, when inserted into the first element, pushes the medicament container into position for delivery of the medicament. The device is further described as using airway deagglomeration features in the body and structural elements for holding and resealing or controlling release of an air burst into the airway via a burst valve formed from a moulded flexible polymer disc with a pyramid and slit structure.
Claims Coverage
The partial content provides two independent claims, a device and a kit. Both independent claims define the same core inventive combination: a two-element, releasably attached multi-unit dose dry powder medicament delivery device using an inner-sleeve shuttle valve that blocks the airway only until priming, with shuttle valve two-orifice geometry and a nozzle stop to arrest shuttle-valve movement, and an actuator spigot that inserts to push the medicament container into delivery position.
Multi-unit dose dry powder medicament delivery device with single use nozzle and inner sleeve airway and cartridge seat
A first element comprising a single use nozzle located in a body at least partially lined with an inner sleeve, the inner sleeve comprising an airway and a cartridge seat.
Releasably attached actuator with air source and valve
A second element adapted to be releasably attached to the first element, the second element comprising an actuator provided with an air source and a valve.
Priming-dependent shuttle valve that blocks the airway until primed
The inner sleeve is provided with a shuttle valve dimensioned such that in the closed position it blocks the airway only until the device is primed by a user.
Two orifices shuttle valve with nozzle stop arresting shuttle-valve movement
The shuttle valve is provided with two orifices and the nozzle is provided with a stop capable of arresting movement of the shuttle valve.
Spigot insertion that pushes the medicament container into position
The actuator comprises a spigot element which, when inserted into the first element, pushes the medicament container into position for delivery of the medicament.
Kit including at least one cartridge with dry powder medicament
At least one cartridge comprising a dry powder medicament.
Overall, the independent claims cover a releasably attached, two-element dry powder medicament delivery arrangement in which an inner-sleeve shuttle valve stays closed only until priming, the shuttle valve provides two orifices while a nozzle stop arrests shuttle-valve movement, and an actuator spigot inserts to push the medicament container into a delivery position, with the kit further including at least one dry powder medicament cartridge.
Stated Advantages
Reduces spillage if inverted or shaken.
Provides controlled air burst for powder dispersal with subsequent resealing behavior.
Documented Applications
Intranasal delivery, including dry powder vaccine delivery and delivery of glucagon.
Potential IV infusion bag delivery.
Emergency therapy context.
Configured as a nasal inhaler.
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