Artificial dressing and use of artificial dressing for promoting wound healing
Inventors
TSAI, Yi-Ju • Yeh, Ying-Ting • BAI, Meng-Yi • ZHANG, Yun-Xuan
Assignees
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Publication Number
US-11969518-B2
Publication Date
2024-04-30
Expiration Date
Abstract
The present invention provides an artificial dressing and a use of the artificial dressing for promoting wound healing. The artificial dressing includes a gelatin and a fungal extract.
Core Innovation
The invention provides an artificial wound dressing comprising gelatin stirred with a fungal extract. The artificial dressing has a pore diameter of 54 μm to 172 μm and a porosity of 94% to 96%, and is formed of a gelatin concentration of 0.025 g/mL to 0.05 g/mL and a fungal extract concentration of 0.25 ppm to 200 ppm.
The fungal extract is an Antrodia cinnamomea extract. The artificial dressing is described as promoting wound healing, and the disclosed formulation improves processability when the fungal extract is added to the gelatin.
In disclosed evaluation, a diabetic mouse wound-healing study compares fungal-extract concentrations of 200 ppm and 0.25 ppm with controls including a negative gelatin condition and a positive AQUACEL® foam dressing. The fungal-extract groups show earlier and faster wound closure than the controls, with maximal healing speed occurring earlier than the positive control.
Claims Coverage
The partial content indicates three independent claims. Across these claims, the core inventive features are a gelatin–Antrodia cinnamomea extract composition with specified pore diameter and porosity, specified formulation concentration ranges, and promotion of wound healing, including application at a defined frequency.
Gelatin stirred with Antrodia cinnamomea extract in defined porous dressing
An artificial dressing comprising gelatin stirred with a fungal extract, wherein the artificial dressing has a pore diameter of 54 μm to 172 μm and a porosity of 94% to 96%, and wherein the fungal extract is an Antrodia cinnamomea extract.
Defined gelatin and fungal extract concentration ranges for wound healing
The artificial dressing promotes wound healing, wherein the artificial dressing is formed of a concentration of 0.025 g/mL to 0.05 g/mL of the gelatin and a concentration of 0.25 ppm to 200 ppm of the fungal extract.
Use of gelatin–fungal extract composition to prepare wound-healing dressing
A use of a composition comprising a gelatin and a fungal extract in preparation of an artificial dressing that promotes wound healing, wherein the artificial dressing comprises the gelatin stirred with the fungal extract and has a pore diameter of 54 μm to 172 μm and a porosity of 94% to 96%.
Application schedule for wound healing using the porous dressing
A use of an artificial dressing in promotion of wound healing, wherein the artificial dressing comprises a gelatin stirred with a fungal extract and is applied to an individual with a wound at a frequency of two days, wherein the artificial dressing has a pore diameter of 54 μm to 172 μm and a porosity of 94% to 96%.
Across the independent claims, the document focuses on a porous artificial wound dressing formed by stirring gelatin with an Antrodia cinnamomea extract, using defined pore diameter and porosity ranges, defined gelatin and fungal extract concentration ranges, and wound-healing use.
Stated Advantages
Improves processability when the fungal extract is added to gelatin.
Provides an antibacterial effect.
Promotes wound healing, including earlier and faster wound closure in fungal-extract groups versus negative gelatin and versus a positive AQUACEL® foam control.
Improves overall healing speed, with maximal healing speed occurring earlier than the positive control.
Documented Applications
Diabetic mouse wound-healing study comparing fungal-extract concentrations (200 ppm vs 0.25 ppm) with controls including negative gelatin and positive AQUACEL® foam.
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