Compositions and methods for remediating chemical warfare agent exposed skin
Inventors
Noblitt, Scott • Neas, Edwin D.
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-11969399-B2
Publication Date
2024-04-30
Expiration Date
Abstract
The present invention relates to chemical and biological warfare agent decontaminating compositions and methods for using the same to decontaminate animal skin and wounds thereon exposed to the agents. The compositions may comprise a peracid, a hydroperoxide, and a peroxyacid.
Core Innovation
The invention relates to aqueous chemical and biological warfare agent decontaminating compositions and methods for decontaminating an animal wound exposed to a chemical warfare agent. The decontamination is performed by contacting the wound with a decontaminating composition in an amount sufficient to decontaminate the wound. The decontaminating composition includes active decontaminating compounds, and the active decontaminating compounds consist of peracetic acid, hydrogen peroxide, and acetic acid in specified weight-percent ranges.
The active compounds are defined to consist of peracetic acid in an amount ranging from about 2% to about 6% by weight, hydrogen peroxide in an amount ranging from about 3.2% to about 20% by weight, and acetic acid in an amount ranging from about 2.8% to about 20% by weight. The disclosed decontaminating composition is described as an aqueous composition, and optional components may include stabilizers and magnesium salts, while maintaining the defined active-compound composition.
The invention further encompasses applying the decontaminating composition to wounds and other surfaces by contacting, including soaking, pressurized dispensing, and coating or layering, with formulations described as gel, sol, liquid, lotion, irrigation gel, or spray. The document also frames the invention in terms of oxidative breakdown and decontamination performance, including comparative evaluation against RSDL (potassium 2,3-butanedione monoximate/DAM in MPEG/water) and breakdown kinetics studies of multiple chemical warfare agents.
The problem being solved, as described in the provided summary content, is the need for broad decontamination of animal skin and wounds and of surfaces that have been exposed to chemical warfare agents, including V-series, G-series, and A-series nerve agents and mustard agents. The document emphasizes decontamination outcomes supported by experimental evidence, including in vivo model evaluations and reported protective ratios and dose-lethality outcomes, as well as in vitro breakdown kinetics showing concentration-dependent oxidative breakdown for some agents.
Claims Coverage
The independent claim identified in the partial content is a method claim covering decontamination of an animal wound with an aqueous composition whose active compounds consist of three specified oxidizing agents in defined weight-percent ranges. The dependent claim set refines the covered inventive features by specifying chemical warfare agent types, composition forms, and application/contact modes, with additional refinements regarding stabilizers and an optional fixed contact time.
Animal wound decontamination with defined active oxidizer composition
A method of decontaminating an animal wound exposed to a chemical warfare agent by contacting the wound with a decontaminating composition sufficient to decontaminate the wound, where the decontamination composition comprises active decontaminating compounds and the active decontaminating compounds consist of peracetic acid (about 2% to about 6% by weight), hydrogen peroxide (about 3.2% to about 20% by weight), and acetic acid (about 2.8% to about 20% by weight).
Specified chemical warfare agent types for wound exposure
The method further specifies that the chemical warfare agent is chosen from V-series nerve agents, G-series nerve agents, A-series nerve agents, mustard agents, or combinations thereof.
Selectable aqueous formulation forms for application
The method further provides that the decontamination composition is formulated in one of several selected forms including gel, sol, liquid, lotion, irrigation gel, or spray.
Contact application modes to the wound
The method further provides that the decontamination composition is applied to a wound by soaking, pressurized dispensing, or coating/layering the composition on the wound.
Optional stabilizer selection in the decontaminating composition
The method further includes a decontaminating composition that contains a stabilizer selected from etidronic acid, disodium ethyelendiamine tetraacetic acid, ethylenediaminetetraacetic acid, tetrasodium ethylene diamine tetraacetate, citramalic acid, dipicolinic acid, dipicolinic acid N-oxide, or combinations thereof.
Fixed contact/removal time period of 15 minutes
The method includes performing the decontamination with a period of time of 15 minutes.
Across the independent claim and its refinements, the core claimed coverage centers on contacting an animal wound with an aqueous decontaminating composition whose active compounds consist of peracetic acid, hydrogen peroxide, and acetic acid in specified weight-percent ranges, with further limitations on the chemical warfare agent types, formulation form, application/contact mode, optional stabilizers, and a 15-minute time period.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?